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IMMEDIATE RELEASE

Release No: 369-96
June 20, 1996

$7.3 MILLION AWARDED FOR GULF WAR HEALTH RESEARCH STUDIES

As part of the Clinton Administration's commitment to better understand the illnesses reported by Gulf War veterans, the Departments of Defense and Veterans Affairs announced the award of $7.3 million for 12 research studies to government, non- government and academic institutions on possible causes and treatment of Gulf War veterans' illnesses.

Last spring, the departments sought proposals from government and non-government applicants including universities, hospitals, and research institutions on:

epidemiological studies of health problems of Persian Gulf

veterans related to their service in the Gulf War;

health effects of pyridostigmine bromide use, alone and in combination with other chemicals; and, clinical studies and other research on the causes, modes of transmission and appropriate treatments for Gulf War-related illnesses.

The Broad Agency Announcement issued last May resulted in the submission of 111 scientific proposals. From these submissions, the departments selected 12 proposed investigations after conducting an exhaustive, independent peer-review process. The final selection was made on the basis of scientific merit and program relevancy.

The U.S. Army Medical Research and Materiel Command (USAMRMC) made the awards on behalf of the Departments of Defense, Veterans Affairs, and Health and Human Services.

Note:  A list of the FY 1996 Persian Gulf War Illnesses Research Awards follows.

FY 1996 Persian Gulf War Illness Research Awards

No. Grantee City State Principal Project Title and Grant Period

Investigator Summary Value of Performance

1. Klemm Analysis Washington D.C. Rebecca J. Epidemiological $779K 1Jun96-31Jan99 Group, Inc Klemm, PhD Studies Persian Gulf 1785 Massachusetts War Illnesses, Persian Avenue, N.W. Gulf Women's Health

Linkage Study

Summary: This

research addresses the

effects of Gulf War

service on military

women's health. The

studies will compare

the incidence,

prevalence, general

health outcomes, and

risks of women

deployed in the Gulf

War theater of

operations with Gulf

War era women who were

not deployed to the Gulf.

2. Georgetown Washington D.C. Daniel Dysregulation of the $971K 6May96-6June96 University Medical Clauw, MD Stress Response in the Center Persian Gulf Syndrome Grant/Contract Summary: This study Office will attempt to show 2115 Wisconsin that abnormalities in Avenue, N.W. 108 some of the

neurohormones

important in human

response to stress are

at least partly

responsible for some

of the unexplained

symptoms suffered by

some Gulf War veterans

as well as symptoms in

other conditions such

as chronic fatigue

syndrome,

fibromyalgia,

somatoform disorder,

and multiple chemical

sensitivity.

3. Boston University Boston Mass Roberta F. Neuropsychological $353K 1May96-1Jun99 Medical Campus . White PhD Functioning in Persian 801 E. Concord Gulf War Veterans Street, Building 560 Summary: This

research will study

whether Gulf War

veterans show

cognitive impairments

suggestive of central

nervous system damage

at a greater rate than

veterans who were not

deployed to the Gulf.

4. University of North Chapel Hill N.C. David H. Effects of $354K 1Jul96-31Jul98 Carolina Overstreet, Pyridostigmine in

PhD Flinders - Line Rats

Differing in

Cholinergic

Sensitivity

Summary: This

research will study

the possibility that

some of the

individuals reporting

adverse reactions to

pyridostigmine may

have had predisposing

genetic conditions

that made them more

sensitive to

pyridostigmine and

contributed to

symptoms of multiple

chemical sensitivity

after exposure to

pyridostigmine.

5. Lovelace Biomedical Albuquerque N.M. Hsu-Chi Characterization of $283K 7Jun96-6Jul98 and Environmental Yeh, PhD Emissions from Heaters Research Institute, Burning Leaded Diesel Inc. Fuel in Unvented Tents P.O. Box 5890 Summary: This

research will provide

detailed information

on pollutants produced

in unvented tents from

heaters that burn

leaded diesel fuels.

This information is

needed to assess

potential exposure of

service personnel who

served in the Gulf War.

6. March of Sacramento Calif. John A. Feasibility of $427K 1Jun96-30Jun98 Dimes/California Harris, MD Investigating Whether Birth Defects There is a Monitoring Program Relationship Between 3031 F. Street, Birth Defects and Suite 200 Service in the Gulf

War Summary: This

research will attempt

to determine if all

children born to Gulf

War veterans living in

California can be

identified and if

congenital birth

defects diagnosed

during the first year

of life can be identified

as well.

7. University of Texas Dallas Texas Ronald G. Fatigue in Persian $554K 15Jun96-14Jul98 Southwestern Haller, MD Gulf Syndrome - Medical Center at Physiologic Mechanisms Dallas Summary: This

research addresses the

symptom of abnormal

fatigue in Gulf War

veterans. The study

will examine the

possibility that

mechanisms used by

muscle cells to use

oxygen and produce

energy for work may be

impaired in patients

suffering abnormal

muscle fatigue and the

inability to exercise.

8. University of Gainesville Fla . Franz van Neurobehavioral and $934K 1May96-1Jun99 Florida Haaren, PhD Immunological Toxicity Box 115500 of Pyridostigmine, 219 Grinter Hall Permethrin and DEET in

Male and Female rats

Summary: This multi-

disciplinary study

using male and female

rats will examine any

neurobehavioral

toxicity and immune

response alterations

after exposure to

pyridostigmine

bromide, permethrin

and DEET alone and in

combinations. Human

lymphocyte cells will

also be studied for

inhibition of immune

response as a result

of exposures to these

materials.

9. Infectious Disease Seattle Wash Steven G. Diagnostic Antigens of $611K 1Jun96-31May98 Research Institute . Reed, PhD Leishmania tropica 1124 Columbia, Summary: This Suite 464 research will attempt

to develop a sensitive

method to detect

infection with

Leishmania tropica, or

related species, in

military personnel.

10. King's College London United Simon A Controlled $865K 1Jun96-30Jun99 School of Medicine Kingdom Wessely, MD Epidemiological and and the Institute of Clinical Study into Psychiatry the Effect of Gulf 103 Denmark Hill War Service on

Servicemen and Women

of the United Kingdom

Armed Forces

Summary: This

research addresses

the prevalence of

unexplained

illnesses, including

chronic fatigue-like

symptoms, in members

of the United Kingdom

Armed Forces who were

deployed to the

Persian Gulf during

the Gulf War and who

have served, and are

serving in Bosnia.

11. VA Connecticut West Haven Conn. Steven Psychological and $264K 7Jun96-6Jul99 Healthcare System Southwick, Neuro-biological

MD Consequences of the

Gulf War Experience

Summary: This

research will

continue to follow

the course of

symptoms of Post-

Traumatic Stress

Disorder in a

population of Gulf

War veterans. This

study of how such

symptoms, as well as

memory function,

change over time in

the veterans will

lead to a better

understanding of PTSD

and the elements of

risk that would cause

and continue PTSD

symptoms over time.

12. Trustees of the Philadelphia Pa. Krista Evaluation of Muscle $906K 15Jun96-14Nov99 University of Vandenborne, Function in Persian Pennsylvania PhD Gulf Veterans

Summary: This

research addresses the

causes ongoing chronic

fatigue and muscle

weakness in Gulf War

veterans with

unexplained illnesses.

The study will be a

comprehensive,

multidisciplinary

approach to evaluate

abnormalities in

skeletal muscle

function in Gulf War

veterans.

Note: In October 1994, President Clinton signed into law legislation (Public Law 103-337, Section 722) which provides for this independent and competitively-bid, peer-reviewed research on the possible health consequences of service in Southwest Asia during the Persian Gulf War.