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Hello , everyone , and thank you for 

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joining this briefing today . Thanks to 

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President Trump's unwavering support 

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for Operation Warp Speed , we have more 

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good news to report this week . 

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Yesterday , the FDA released an 

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internal assessment of the Pfizer 

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vaccines trial data . The FDA 

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assessment showed that the vaccine was 

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around 95% effective , was efficacious 

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across different groups , including the 

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elderly and people with co morbidity 

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ease and did not show any significant 

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safety concerns . This analysis is 

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being presented tomorrow to the FDA is 

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Vaccines and Related Biological 

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Products Advisory Committee , which 

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will weigh in for the agency's 

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consideration on whether they believe 

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the vaccine meets the criteria for 

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emergency use authorization . We could 

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then have an easy way within days and 

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be administering doses of vaccine to 

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our most vulnerable next week , as 

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we've discussed , based on current 

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production schedules , we expect to 

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have enough doses to vaccinate 20 

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million Americans by the end of this 

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year , 50 million total by the end of 

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January and at least 100 million total 

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by the end of the first quarter . We 

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remain confident that across our 

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portfolio of multiple vaccines , we 

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will have enough doses for any American 

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who wants a vaccine . By the end of the 

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second quarter of 2021 as we've 

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continued to make progress on vaccine 

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development and manufacturing , General 

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Pern and his team have been in close 

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touch with our state partners on how we 

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will be allocating and distributing the 

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doses as they become available . We'll 

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also be releasing MAWR informational 

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material in the coming days and weeks 

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for Americans to help spread the word 

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about the safety and efficacy of the 

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coming vaccines . We also continue to 

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allocate and ship MAWR courses of the 

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two authorized antibody treatments to 

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help Americans at risk for Severe Cove 

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in 19 who have not been hospitalized . 

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As of today , we have now allocated 

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more than 278,000 courses of these 

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treatments . As I've noted in previous 

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weeks , every American who's recovered 

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from Cove in 19 in the past three 

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months can help expand our arsenal of 

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potential treatments for this virus by 

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donating plasma . Millions of Americans 

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have recovered from Cove in 19 in the 

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last several months and could be 

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eligible to donate . Please contact 

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your local American Red Cross or local 

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American blood bank or go to Corona 

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virus dot gov for more information 

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about how you can volunteer to be a 

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donor and give the gift of life , I'll 

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conclude by reminding all Americans 

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that even as we have such a bright 

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future ahead , we face extremely 

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concerning trends in the spread of the 

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virus . Hospitalization rates are now 

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at the highest they have been during 

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the pandemic . We're so close to being 

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able to protect millions of Americans 

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from this virus with the vaccine . For 

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now , we need to double down on the 

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steps that can keep us all safe . The 

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three W's Wash your hands , Watch your 

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distance where face covering . You 

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can't watch your distance and avoid 

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places like indoor settings and crowded 

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out crowded settings where you can't do 

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those things . Those public health 

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measures are the safe bridge to a 

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vaccine . Thank you again for joining 

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us , and I'll now hand things over to 

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Dr Slowey to give us updates on the 

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vaccine development front . Thank you , 

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Mr Secretary . Hi , everybody . So just 

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a few comments to add on build upon 

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what Mr Secretary has said . Clearly 

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great focus on the FDA had come 

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tomorrow and then and then a week from 

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tomorrow reviewing the fighter and then 

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the modern vaccines . Probably most of 

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you have now had a chance to look into 

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the fighters . Submission . I'll be 

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happy . Thio Address any questions you 

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may have there with quite remarkable 

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FXC , I think . Very good safety 

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profile , mostly injection site and 

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injection related adverse events . 

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One of the points I'd like to attract 

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your attention attention to is the 

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captain Mayor curve That shows that 

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within 12 days or so from the first 

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dose of vaccine , the number of cases 

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in the study vaccine arm flattens and 

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continue to remain flat after the 

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second does . But the key point is 

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already after the first dose , and if 

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you study the misogynistic data , 

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you'll see that there is barely 

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detectable neutralizing antibodies at 

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that time . There is already very , 

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very significant protection induced . I 

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think it's very important because 

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hopefully we will start impacting 

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people's lives very quickly after the 

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onset off the campaigns to immunize . 

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And secondly , it's something that 

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makes us very mawr , uh , 

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optimistic . In regard of the young 

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since Vaccine J and J that , as you 

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know , is being tested as one . Those 

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vaccine , probably in a few days , the 

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Moderna booklet will be published and 

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you will see that the data are as as 

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impressive and compelling regarding the 

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J and J vaccine . But I said it's a one 

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shot vaccine . Actually , there is a 

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There is a second face retrial that has 

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a two shots vaccine . But what we 

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consider to be a breakthrough in terms 

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of intervention into the pandemic could 

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be the one shot vaccine where 

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optimistic efficacy could be very high . 

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We have already recruited more than 

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38,000 subjects in this study we jnj . 

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We decided to cap the recruitment to 

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around 40,000 subjects , which will 

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happen by the end of this week in the 

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next 23 days , and given the attack 

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rate into the city and in the countries 

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where the city has been conducted , it 

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is very likely that we will have our 

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first views on FXC for this vaccine 

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very early in the month of January and 

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that somewhere in the late of the month 

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of January or early February anyway 

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would be submitted and hopefully 

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approved swiftly . We may 

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be able to accumulate another 30 to 

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40 million vaccines in the month of 

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February if this vaccine gets 

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approved and an equivalent number or 

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slightly higher going forward in the 

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month of March , etcetera . So 

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important thanks to keep in mind , 

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uh , in terms of impact on the on the 

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pandemic . Also the AstraZeneca vaccine . 

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We have now about 18,000 subjects 

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recruited in the U . S . Conducted face 

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retrial That's under the oversight off 

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Operation War speed . There are no 

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different dosages . There's no 

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different batches of vaccine . That 

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study , we believe , is going to give a 

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clear outcome as to the efficacy and 

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safety of the vaccine on . We again 

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look forward to potentially reading out 

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from that study on its efficacy 

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somewhere late in the month of January 

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and if positive anyway , maybe filed 

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somewhere in late in the month off 

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February with final analysis data on 

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the protein vaccine side , which is the 

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third platform technology . As you know , 

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that we have in the portfolio . We have 

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very good progress with Novavax 

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that is gearing up Thio start its 

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face retrial and we have some further 

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analysis ongoing and discussions with 

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Sanofi Thio . See what the next steps 

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in progressing the vaccine . They're 

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towards phase three , so things are 

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moving in the right direction on Happy 

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to address your questions and pass on 

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to my coup leader general partner to 

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tell you more about how these vaccines 

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are gonna make it into people . Thank 

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you , Dr Slowly . And Mr Secretary . 

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Thank you . Eso uh , you know , just 

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exciting time to be in the business 

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that we're in right now . Uh , 

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supporting this through logistics and 

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eventual sustainment . Uh , vaccine 

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distribution , uh , and resupply 

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accordingly . So , uh , we are focused 

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on our micro planning A to the state 

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jurisdiction level , uh , reminder of 

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the triad that's involved in this . The 

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C d . C . Experts who developed 

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the strategy who have been working day 

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to day with states for the last six 

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months . Um , the commercial industry 

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partners , McKesson , FedEx , ups , uh , 

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Walgreen , CVS , and many others 

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who are working their plans every day 

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to make them better . And then , of 

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course , the states right , our ability 

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to enable their priorities on their 

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plans is what really will determine our 

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success . Every day that goes by , we 

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get stronger on this , but eventually , 

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right , we're going toe , have a new 

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way , right not to get out in front of 

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that decision . But to be prepared for 

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it . Uh , this week , This past Friday , 

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all the jurisdictions , all 64 

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jurisdictions and five federal agencies 

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locked in their micro plans for the 

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Pfizer vaccine . So based on their , uh , 

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their allocation of vaccine , which we 

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provided to them , we locked in 636 

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locations by quantity vaccine 

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delivery if and when the vaccine is 

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approved a zai I've talked about , we 

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will begin , um , upon approval of the 

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U A . Packing to the micro plans and 

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district begin distribution within 24 

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hours out to the jurist addictions . 

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Accordingly , our goal is to make sure 

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that we can ensure the vaccine is 

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delivered on in a timely manner is 

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delivered safely securely on . It's 

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ready to be utilized to start 

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administering , uh , vaccine as soon as 

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possible . To that end , what we also 

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already did I gave permission toe 

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already distribute syringes and needles . 

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Alcohol wipes on dilute , which is 

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required in support of the Pfizer 

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vaccine , will begin that today . It 

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will be distribution will be completed 

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by Friday again on Lee to set 

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conditions . And if it sits there for 

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another week or 10 days or whatever , 

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then it does , but planning for success , 

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We wanted to make sure that the states 

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had all that they needed toe have , um , 

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this week , Uh , we're focusing not on 

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Lee on the final , Uh , uh , planning 

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for the Pfizer vaccine , But we're in 

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deep coordination for the micro plans 

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for the modern A vaccine . So last 

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night , final lock of allocations were 

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provided to the jurisdictions . Uh , 

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today , tomorrow and Friday they will 

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lock in locations and quantities and 

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hence will be prepared for follow 

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on , uh , eventual approval of the EU 

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way for Madonna . So great news in the 

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planning world . Really confident , uh , 

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in the collaboration by the CDC with 

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states by the continuous improvement by 

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commercial industry on then the states 

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knowledge and execution of their plans , 

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we continue Thio have conversations 

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with the public health officials across 

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the country . Right ? We're personally 

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talking to them , uh , neither briefing 

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governors with Secretary a czar and Dr 

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Slowey or we are making phone calls 

276
00:11:49,310 --> 00:11:51,720
individually to governors . But more 

277
00:11:51,720 --> 00:11:54,000
importantly , helping the health 

278
00:11:54,000 --> 00:11:56,310
experts who advise governors on their 

279
00:11:56,310 --> 00:11:58,310
plans , You know , in the army , we 

280
00:11:58,310 --> 00:12:00,430
call this battlefield circulation to 

281
00:12:00,430 --> 00:12:03,460
assess you know where everybody is to 

282
00:12:03,460 --> 00:12:06,660
help focus toe add enablers if 

283
00:12:06,660 --> 00:12:10,150
required to fine tune etcetera on DSO . 

284
00:12:10,150 --> 00:12:13,010
We're working this virtual circulation 

285
00:12:13,020 --> 00:12:16,160
with everybody very powerful sessions 

286
00:12:16,160 --> 00:12:18,049
that it's allowing us to identify 

287
00:12:18,049 --> 00:12:20,460
things ahead of time . Several calls , 

288
00:12:20,470 --> 00:12:22,640
you know , I've said , General , 

289
00:12:22,650 --> 00:12:24,817
they've said , General , we'd like you 

290
00:12:24,817 --> 00:12:26,872
to consider something . Absolutely . 

291
00:12:26,872 --> 00:12:29,094
That's why we're calling CDCs up on the 

292
00:12:29,094 --> 00:12:31,150
phone , commercial industries on the 

293
00:12:31,150 --> 00:12:33,206
phone , that states are on the phone 

294
00:12:33,206 --> 00:12:35,206
and we're solving problems ahead of 

295
00:12:35,206 --> 00:12:37,710
execution . Does this mean perfection ? 

296
00:12:37,720 --> 00:12:40,410
No plan is only good to get you started . 

297
00:12:40,840 --> 00:12:42,750
What is important is the open 

298
00:12:42,750 --> 00:12:45,420
communication and collaboration between 

299
00:12:45,420 --> 00:12:48,980
the triad to sustain , to develop plans , 

300
00:12:48,990 --> 00:12:51,120
get ahead of problems and be ready to 

301
00:12:51,120 --> 00:12:54,350
execute really , really appreciate 

302
00:12:54,350 --> 00:12:56,239
those phone calls collectively by 

303
00:12:56,239 --> 00:12:59,010
everybody . Finally , we're working on 

304
00:12:59,020 --> 00:13:01,810
education materials for the vaccine . C . 

305
00:13:01,810 --> 00:13:04,730
D . C . Is doing excellent work they've 

306
00:13:04,730 --> 00:13:07,640
already posted on their Web page . 

307
00:13:07,640 --> 00:13:10,780
Significant education , uh , 

308
00:13:10,790 --> 00:13:12,930
information and tools for the Pfizer 

309
00:13:12,930 --> 00:13:16,250
vaccine on how toe work through it . It 

310
00:13:16,250 --> 00:13:19,660
will be updated based on FDA guidance 

311
00:13:19,660 --> 00:13:23,110
on and the A sip guidance , right ? So 

312
00:13:23,110 --> 00:13:25,277
it's not the conclusion yet , but it's 

313
00:13:25,277 --> 00:13:27,400
allowing people to get involved and 

314
00:13:27,400 --> 00:13:29,660
start to really see things , so they're 

315
00:13:29,660 --> 00:13:31,938
not learning things at the last minute , 

316
00:13:31,938 --> 00:13:34,160
right ? Everything that's admissible to 

317
00:13:34,160 --> 00:13:37,160
be provided is being sent out on will 

318
00:13:37,160 --> 00:13:39,380
be updated accordingly . Really , 

319
00:13:39,390 --> 00:13:41,730
really important . Piece toe what we're 

320
00:13:41,730 --> 00:13:44,000
doing . So , at the end of the day , 

321
00:13:44,010 --> 00:13:46,232
I'm very excited about where we're at . 

322
00:13:46,540 --> 00:13:48,760
If you're in my profession and you're 

323
00:13:48,760 --> 00:13:50,760
not excited , you ought to be doing 

324
00:13:50,760 --> 00:13:53,840
something else . I feel confident that 

325
00:13:53,840 --> 00:13:56,930
we've done uh , detailed planning . We 

326
00:13:56,930 --> 00:13:59,660
worked through rehearsals . We have 

327
00:13:59,660 --> 00:14:02,920
checked . What if Fox on ? We continue 

328
00:14:02,920 --> 00:14:05,760
to learn every day in preparation for 

329
00:14:05,770 --> 00:14:08,260
eventual distribution . Mr . Secretary . 

330
00:14:08,270 --> 00:14:10,603
Great . Thank you , General . Thank you , 

331
00:14:10,603 --> 00:14:12,826
Doctor . Doctor Slowey and Michael , if 

332
00:14:12,826 --> 00:14:14,937
you wanna get us started on questions 

333
00:14:14,937 --> 00:14:16,881
from the media . Thank you , sir . 

334
00:14:16,881 --> 00:14:19,048
Thank you all . Operator . We will now 

335
00:14:19,048 --> 00:14:21,270
open it up for questions and a friendly 

336
00:14:21,270 --> 00:14:23,437
reminder that when asking a question , 

337
00:14:23,437 --> 00:14:23,260
please state your name and publication 

338
00:14:23,640 --> 00:14:25,473
and keep your questions short as 

339
00:14:25,473 --> 00:14:27,362
possible so we can get to as many 

340
00:14:27,362 --> 00:14:29,584
questions as we can in the time that we 

341
00:14:29,584 --> 00:14:31,751
have and I'll turn it over to you know 

342
00:14:31,751 --> 00:14:33,751
Operator ? Yes , thank you . If you 

343
00:14:33,751 --> 00:14:35,862
would like to ask a question , please 

344
00:14:35,862 --> 00:14:37,973
Press star one , I'll meet your phone 

345
00:14:37,973 --> 00:14:37,600
and record your name and outlet . 

346
00:14:37,600 --> 00:14:39,767
Clearly , if you need to withdraw your 

347
00:14:39,767 --> 00:14:41,933
question , please Dial Star Thio again 

348
00:14:41,933 --> 00:14:43,989
to ask a question , please Dial Star 

349
00:14:43,989 --> 00:14:45,989
one . Our first question comes from 

350
00:14:45,989 --> 00:14:48,530
Kevin Brown from Fox News . Kevin , 

351
00:14:48,540 --> 00:14:51,530
your line is open . Good afternoon . 

352
00:14:51,530 --> 00:14:53,530
It's it's Evan Brown . Thank you so 

353
00:14:53,530 --> 00:14:55,750
much . Um , uh , two questions there 

354
00:14:55,750 --> 00:14:57,972
really quickly . The U K . Has reported 

355
00:14:57,972 --> 00:15:00,050
ah , few cases of people having an 

356
00:15:00,050 --> 00:15:01,828
allergic reaction , and they're 

357
00:15:01,828 --> 00:15:03,772
advising some people who know they 

358
00:15:03,772 --> 00:15:05,830
might have allergic reactions to not 

359
00:15:05,830 --> 00:15:08,200
get the vaccine . Is there a similar 

360
00:15:08,210 --> 00:15:10,980
request or order that would come from 

361
00:15:10,980 --> 00:15:13,147
American authorities on this ? Telling 

362
00:15:13,147 --> 00:15:15,202
people Hey , you should not get this 

363
00:15:15,202 --> 00:15:17,440
vaccine . And second of all , when does 

364
00:15:17,440 --> 00:15:20,790
a you A , uh , evolve into , um , or 

365
00:15:20,790 --> 00:15:24,150
permanent approval for either these 

366
00:15:24,150 --> 00:15:26,261
vaccines or any vaccines in general ? 

367
00:15:26,261 --> 00:15:28,770
Great . Evan , let me answer the second 

368
00:15:28,770 --> 00:15:30,937
question , and then I'll pass it to Dr 

369
00:15:30,937 --> 00:15:32,826
Slowly to speak about the British 

370
00:15:32,826 --> 00:15:34,890
incident that's been reported so in 

371
00:15:34,890 --> 00:15:38,710
terms of , uh , E way versus the full 

372
00:15:38,720 --> 00:15:41,560
biologic license is called a B L . A . 

373
00:15:42,040 --> 00:15:43,873
This is actually a fairly unique 

374
00:15:43,873 --> 00:15:47,060
circumstance here because the FDA has 

375
00:15:47,070 --> 00:15:49,760
through there you a guidance on covert 

376
00:15:49,760 --> 00:15:53,530
vaccines actually required a very high 

377
00:15:53,530 --> 00:15:56,280
standard of data on safety . Efficacy 

378
00:15:56,280 --> 00:15:58,610
and manufacturing compared actually tow 

379
00:15:58,610 --> 00:16:01,530
what the statute requires for emergency 

380
00:16:01,530 --> 00:16:03,752
use authorization . They're effectively 

381
00:16:03,752 --> 00:16:07,570
holding these vaccines very close to 

382
00:16:07,570 --> 00:16:09,792
the evidentiary standard required for a 

383
00:16:09,792 --> 00:16:11,959
biologic license . So , for instance , 

384
00:16:11,959 --> 00:16:14,070
each clinical trials required to have 

385
00:16:14,070 --> 00:16:16,280
30,000 people in it . That's extremely 

386
00:16:16,280 --> 00:16:18,920
large for a vaccine clinical trial . 

387
00:16:19,180 --> 00:16:21,910
They're requiring 60 days of safety 

388
00:16:21,910 --> 00:16:24,160
data from the median patient visit . 

389
00:16:24,610 --> 00:16:27,010
90% of adverse events with the vaccine 

390
00:16:27,010 --> 00:16:29,620
usually occur within the 1st 42 days . 

391
00:16:30,040 --> 00:16:32,180
All of the statistical significance 

392
00:16:32,180 --> 00:16:34,900
requirements for efficacy are the same 

393
00:16:34,900 --> 00:16:36,956
that they would have been for a full 

394
00:16:36,956 --> 00:16:39,180
license so up everything I just laid 

395
00:16:39,180 --> 00:16:42,190
out there is what a manufacturer would 

396
00:16:42,190 --> 00:16:44,412
have done for a full on license . There 

397
00:16:44,412 --> 00:16:46,560
really are two principal differences 

398
00:16:46,560 --> 00:16:48,782
between an emergency authorization , as 

399
00:16:48,782 --> 00:16:51,340
we'll be seeing here potentially versus 

400
00:16:51,340 --> 00:16:54,270
the full biologic license . One is long 

401
00:16:54,270 --> 00:16:56,048
term safety that , of course of 

402
00:16:56,048 --> 00:16:58,460
necessity you don't have years of data 

403
00:16:58,690 --> 00:17:01,110
of safety information with A with a 

404
00:17:01,110 --> 00:17:04,060
normal product going through the system 

405
00:17:04,190 --> 00:17:06,412
because you wouldn't have had operation 

406
00:17:06,412 --> 00:17:07,968
warp speed doing commercial 

407
00:17:07,968 --> 00:17:10,079
manufacturing at the same time as the 

408
00:17:10,079 --> 00:17:12,301
developed development process you would 

409
00:17:12,301 --> 00:17:14,720
have had them time for ongoing safety 

410
00:17:14,720 --> 00:17:16,553
monitoring before you ever had . 

411
00:17:16,553 --> 00:17:18,690
Vaccine released here will have 

412
00:17:18,700 --> 00:17:21,430
extremely aggressive what's called Phar 

413
00:17:21,430 --> 00:17:24,060
Maco Vigilance Program , which is part 

414
00:17:24,060 --> 00:17:26,227
of what General Purna and the CDC have 

415
00:17:26,227 --> 00:17:28,580
orchestrated with our states to very 

416
00:17:28,580 --> 00:17:31,610
aggressively monitor as more and more 

417
00:17:31,610 --> 00:17:34,140
people are vaccinated for any type of 

418
00:17:34,140 --> 00:17:35,973
safety signals , safety events , 

419
00:17:35,973 --> 00:17:38,196
etcetera . So that's part of that . But 

420
00:17:38,196 --> 00:17:40,350
again , 60 days of patient visit data 

421
00:17:40,620 --> 00:17:42,740
90% of adverse events and vaccines , 

422
00:17:42,740 --> 00:17:45,040
usually with the 1st 42 days so well 

423
00:17:45,040 --> 00:17:46,984
within that window . The second is 

424
00:17:46,984 --> 00:17:49,318
really around manufacturing . Obviously , 

425
00:17:49,318 --> 00:17:51,540
the FDA for emergency use authorization 

426
00:17:51,540 --> 00:17:53,373
will be validating manufacturing 

427
00:17:53,373 --> 00:17:55,450
quality to ensure consistency of 

428
00:17:55,450 --> 00:17:57,339
product from what was done in the 

429
00:17:57,339 --> 00:17:59,228
clinical trials to what's used in 

430
00:17:59,228 --> 00:18:01,450
commercial scale for a full on biologic 

431
00:18:01,450 --> 00:18:03,617
license . They actually will run . Try 

432
00:18:03,617 --> 00:18:05,672
a lots in the manufacturing facility 

433
00:18:05,672 --> 00:18:08,360
under FDA inspection that tends to take 

434
00:18:08,540 --> 00:18:12,160
another several months after what now 

435
00:18:12,170 --> 00:18:15,240
you a would be that comes out . So be 

436
00:18:15,240 --> 00:18:17,890
thinking approximately four orm or 

437
00:18:17,890 --> 00:18:20,920
months after the U A . Issues that the 

438
00:18:20,920 --> 00:18:23,210
products might be subject to a full on 

439
00:18:23,220 --> 00:18:25,790
final biologic license . But now Dr 

440
00:18:25,790 --> 00:18:27,980
Slow , we have certainly correct me is 

441
00:18:27,980 --> 00:18:30,147
the expert on vaccine development if I 

442
00:18:30,147 --> 00:18:32,369
if there's anything you want to correct 

443
00:18:32,369 --> 00:18:34,647
on that front But then on the UK issue , 

444
00:18:34,647 --> 00:18:37,060
please . I were a spot on Mr Secretary 

445
00:18:37,070 --> 00:18:40,520
regarding the allergic reactions . Uh , 

446
00:18:40,530 --> 00:18:42,586
our understanding is two health care 

447
00:18:42,586 --> 00:18:45,230
workers who were known to have severe 

448
00:18:45,230 --> 00:18:48,360
allergic reactions in the sense that 

449
00:18:48,360 --> 00:18:51,230
they had both EpiPens on them and they 

450
00:18:51,230 --> 00:18:53,930
carry them all the time . So that tells 

451
00:18:53,930 --> 00:18:57,570
me they are known to have 

452
00:18:57,880 --> 00:19:00,690
severe allergic reactions , have had 

453
00:19:00,890 --> 00:19:03,660
what has bean terms and an F electorate 

454
00:19:03,740 --> 00:19:07,280
reaction , which which is a systemic 

455
00:19:07,640 --> 00:19:10,940
as well as local reaction but not life 

456
00:19:10,950 --> 00:19:13,340
threatening . And they probably , I 

457
00:19:13,340 --> 00:19:15,451
assume that I don't know , for a fact 

458
00:19:15,720 --> 00:19:19,180
injected themselves with the EpiPen and 

459
00:19:19,180 --> 00:19:21,770
therefore the reaction resolved , uh , 

460
00:19:22,620 --> 00:19:24,760
looking into the data 

461
00:19:26,340 --> 00:19:28,760
patients or subjects with severe 

462
00:19:28,960 --> 00:19:31,120
allergic reaction history have been 

463
00:19:31,120 --> 00:19:33,120
excluded from the clinical trials , 

464
00:19:33,440 --> 00:19:37,180
which is classic . So my 

465
00:19:37,190 --> 00:19:39,680
expectation is that this is new news . 

466
00:19:40,140 --> 00:19:42,980
Uh , and I would assume , but of course , 

467
00:19:42,980 --> 00:19:45,147
the FDA will make those decisions that 

468
00:19:45,147 --> 00:19:47,036
tomorrow this will be part of the 

469
00:19:47,036 --> 00:19:49,880
consideration . And as in the UK , the 

470
00:19:49,880 --> 00:19:52,100
expectation would be the subjects with 

471
00:19:52,100 --> 00:19:54,080
known severe reaction . Allergic 

472
00:19:54,080 --> 00:19:56,660
reactions should not take the vaccine 

473
00:19:57,040 --> 00:19:58,873
until we understand exactly what 

474
00:19:58,873 --> 00:20:01,170
happened here . Great . Thank you . We 

475
00:20:01,170 --> 00:20:03,059
could turn to the next question , 

476
00:20:03,059 --> 00:20:05,170
please . Our next question comes from 

477
00:20:05,170 --> 00:20:07,620
Sarah over mall from Politico . Sarah , 

478
00:20:07,620 --> 00:20:10,780
your line is open . Thank you . Um , I 

479
00:20:10,780 --> 00:20:12,947
wanted to ask about states allocations 

480
00:20:12,947 --> 00:20:15,169
of vaccines . Um , General partner said 

481
00:20:15,169 --> 00:20:17,300
that those were just finalized . Um , 

482
00:20:17,300 --> 00:20:19,570
why did certain allocations decreased 

483
00:20:19,580 --> 00:20:21,691
before they're finalized ? And then , 

484
00:20:21,691 --> 00:20:23,524
um according to this Wall Street 

485
00:20:23,524 --> 00:20:25,691
Journal article that was breaking down 

486
00:20:25,691 --> 00:20:28,320
the expected allocations . Um , organs 

487
00:20:28,320 --> 00:20:30,264
getting roughly the same amount of 

488
00:20:30,264 --> 00:20:32,264
Alaska when they have six times the 

489
00:20:32,264 --> 00:20:34,487
population . So it's just done based on 

490
00:20:34,487 --> 00:20:36,709
population . Why are there numbers like 

491
00:20:36,709 --> 00:20:38,876
that , General ? Okay , so just , uh , 

492
00:20:38,876 --> 00:20:41,380
maybe a refresher . Uh , we're 

493
00:20:41,390 --> 00:20:44,970
allocating , uh , by , uh , by 

494
00:20:44,970 --> 00:20:48,400
population a pro rata to the available 

495
00:20:48,400 --> 00:20:51,160
vaccine . When I snapped the chalk line , 

496
00:20:51,540 --> 00:20:54,970
vaccine comes off through manufacturing 

497
00:20:54,970 --> 00:20:58,310
to fill finish , Um , Onley . When I'm 

498
00:20:58,310 --> 00:21:01,640
confident that it's been approved for 

499
00:21:01,650 --> 00:21:05,000
final distribution , does it count , uh , 

500
00:21:05,010 --> 00:21:08,320
for us to distribute ? When I snap the 

501
00:21:08,320 --> 00:21:11,230
chalk line on that number , then what 

502
00:21:11,230 --> 00:21:13,070
we do is we take the pro rata 

503
00:21:13,070 --> 00:21:16,870
population of above 18 years old . We 

504
00:21:16,870 --> 00:21:19,330
allocate that number , and hence we 

505
00:21:19,330 --> 00:21:22,290
develop allocations to all the 

506
00:21:22,290 --> 00:21:24,770
jurisdictions and five federal agencies 

507
00:21:24,780 --> 00:21:28,340
accordingly . So an example . The 

508
00:21:28,350 --> 00:21:30,820
Pfizer vaccine on Lee had x amount 

509
00:21:30,830 --> 00:21:32,950
available that was approved for 

510
00:21:32,950 --> 00:21:35,660
distribution when I snapped the chalk 

511
00:21:35,660 --> 00:21:37,950
line two weeks ago because I wanted the 

512
00:21:37,950 --> 00:21:39,920
state's toe have time to do micro 

513
00:21:39,920 --> 00:21:43,030
planning to that number . A week later , 

514
00:21:43,040 --> 00:21:45,740
when we were talking about allocating 

515
00:21:45,740 --> 00:21:47,830
to Madonna , there was a different 

516
00:21:47,840 --> 00:21:50,780
amount available on I snapped the chalk 

517
00:21:50,780 --> 00:21:53,980
line . We did the way , did the formula 

518
00:21:53,990 --> 00:21:55,960
and hence they have a different 

519
00:21:55,960 --> 00:21:58,350
allocation . It will bounce back and 

520
00:21:58,350 --> 00:22:00,780
forth week the week based on 

521
00:22:00,790 --> 00:22:02,910
availability of vaccines that are 

522
00:22:02,910 --> 00:22:05,790
approved for distribution . But are 

523
00:22:05,790 --> 00:22:08,050
formula for distribution remains the 

524
00:22:08,050 --> 00:22:11,540
same . The states will then 

525
00:22:11,550 --> 00:22:15,320
prioritize inside of the E 

526
00:22:15,320 --> 00:22:18,760
u A FDA , you a guidance and the CDC 

527
00:22:19,240 --> 00:22:22,890
uh , a sip Guidance on . They will 

528
00:22:22,890 --> 00:22:25,450
figure out what groups to prioritized 

529
00:22:25,460 --> 00:22:28,470
inside of that , I think . Good . 

530
00:22:29,440 --> 00:22:32,100
Yeah . Next question , please . Our 

531
00:22:32,100 --> 00:22:34,050
next question comes from Angelika 

532
00:22:34,060 --> 00:22:36,530
Angelika . Excuse me , Angelica . Live 

533
00:22:36,530 --> 00:22:38,650
Edo from Bloomberg News . Angelica , 

534
00:22:38,650 --> 00:22:40,910
your line is open . Thank you for 

535
00:22:40,910 --> 00:22:43,180
taking my question . When will 

536
00:22:43,180 --> 00:22:45,390
operation warp speed publicize the 

537
00:22:45,400 --> 00:22:47,567
state and jurisdiction allocations And 

538
00:22:47,567 --> 00:22:49,844
if it does not plan to publicize these , 

539
00:22:49,844 --> 00:22:53,690
why not , General ? So right now we 

540
00:22:53,700 --> 00:22:57,580
way publicized the allocations by state 

541
00:22:57,590 --> 00:23:00,190
to the states . Right ? And so every 

542
00:23:00,190 --> 00:23:03,320
state has their allocation , uh , two 

543
00:23:03,330 --> 00:23:05,274
for the distribution of Pfizer and 

544
00:23:05,274 --> 00:23:08,510
Madonna . Uh , that is a working 

545
00:23:08,520 --> 00:23:11,280
number that we need to utilize the for 

546
00:23:11,280 --> 00:23:14,330
our planning and execution it is based 

547
00:23:14,330 --> 00:23:17,680
on , as I articulated the pro rata to 

548
00:23:17,680 --> 00:23:20,650
the population . Uh , and distribution 

549
00:23:20,650 --> 00:23:23,660
is fair and equitable to everybody . A 

550
00:23:23,660 --> 00:23:26,460
to this time I'm on lee , uh , sharing 

551
00:23:26,460 --> 00:23:29,240
those allocations with states so that 

552
00:23:29,240 --> 00:23:31,296
they could do their micro planning . 

553
00:23:31,296 --> 00:23:33,820
And we can ensure a good , constant 

554
00:23:33,820 --> 00:23:37,070
flow of vaccine , uh , to the entire , 

555
00:23:37,080 --> 00:23:40,880
uh , United States of America . Thank 

556
00:23:40,880 --> 00:23:44,350
you . Next question , please . Our next 

557
00:23:44,350 --> 00:23:46,461
question comes from Katie Thomas from 

558
00:23:46,461 --> 00:23:48,628
The New York Times . Katie , your line 

559
00:23:48,628 --> 00:23:50,710
is open . I just wondered what the 

560
00:23:50,720 --> 00:23:53,390
total estimate is for how many millions 

561
00:23:53,390 --> 00:23:55,557
of doses will go out that first week . 

562
00:23:55,557 --> 00:23:59,370
Is it still 6.4 million ? So 

563
00:23:59,370 --> 00:24:02,160
646.4 million is where I snapped the 

564
00:24:02,160 --> 00:24:04,770
chalk line . Right ? Because that was 

565
00:24:04,770 --> 00:24:07,320
available at the time . You know , over 

566
00:24:07,320 --> 00:24:10,050
two weeks ago on then what we did is I 

567
00:24:10,050 --> 00:24:12,970
pulled some off for some reserve good 

568
00:24:12,980 --> 00:24:16,130
Army General officer planning , right , 

569
00:24:16,130 --> 00:24:18,620
So that we make sure that in case we , 

570
00:24:18,630 --> 00:24:21,720
uh , need to react to some situation we 

571
00:24:21,720 --> 00:24:24,770
had some reserve on . Then I split the 

572
00:24:24,770 --> 00:24:28,410
remaining doses , which was six million 

573
00:24:28,410 --> 00:24:31,830
doses in half on . Then we did the 

574
00:24:31,830 --> 00:24:34,640
allocations accordingly . Our plan is 

575
00:24:34,640 --> 00:24:36,860
to distribute the first dose to the 

576
00:24:36,860 --> 00:24:39,880
American people based on allocation on 

577
00:24:39,880 --> 00:24:42,670
then 21 days for Pfizer . Later , we'll 

578
00:24:42,670 --> 00:24:45,430
ship the second dose on eventually for 

579
00:24:45,430 --> 00:24:48,460
Madonna . It'll be 28 days later but 

580
00:24:48,470 --> 00:24:50,990
snapped the chalk line . 6.4 pulled off 

581
00:24:50,990 --> 00:24:52,940
some reserve divided in half 

582
00:24:52,950 --> 00:24:55,590
distributed . The first half will 

583
00:24:55,590 --> 00:24:58,330
distribute when you is approved . That 

584
00:24:58,330 --> 00:25:00,850
is the method that we're using , uh , 

585
00:25:00,860 --> 00:25:02,970
for the initial distributions . 

586
00:25:02,980 --> 00:25:05,990
Eventually , we will become much more 

587
00:25:05,990 --> 00:25:09,770
confident in our manufacturing , our 

588
00:25:09,770 --> 00:25:13,120
distribution process , state handling , 

589
00:25:13,130 --> 00:25:15,810
etcetera . And then the requirement for 

590
00:25:15,810 --> 00:25:19,350
reserve won't be necessary . A 

591
00:25:19,350 --> 00:25:21,572
total amount that I'm pulling off now . 

592
00:25:22,240 --> 00:25:25,290
Thank you . Next question . Our next 

593
00:25:25,290 --> 00:25:27,512
question comes from Kansas . Story from 

594
00:25:27,512 --> 00:25:30,660
AP . Candace , your line is open . Hey , 

595
00:25:30,670 --> 00:25:32,781
thanks for taking the questions . Can 

596
00:25:32,781 --> 00:25:35,003
you give an update on the status of the 

597
00:25:35,003 --> 00:25:37,003
data use agreements , whether those 

598
00:25:37,003 --> 00:25:39,114
final a handful of jurisdictions have 

599
00:25:39,114 --> 00:25:41,880
signed off on them . And then secondly , 

600
00:25:41,890 --> 00:25:44,190
as more vaccines come online , how are 

601
00:25:44,190 --> 00:25:46,480
you planning for scenarios where people 

602
00:25:46,480 --> 00:25:48,850
might hold out for a particular vaccine , 

603
00:25:49,140 --> 00:25:52,150
For example , everyone wanting the J J 

604
00:25:52,150 --> 00:25:54,660
one shot vaccine and leaving providers 

605
00:25:54,670 --> 00:25:56,960
with stockpiles of two dose vaccine , 

606
00:25:57,840 --> 00:26:00,007
Why don't you start off general ? Then 

607
00:26:00,007 --> 00:26:02,173
we'll turn to Dr Slowly for the second 

608
00:26:02,173 --> 00:26:04,530
question . So , uh , first one D e U S , 

609
00:26:04,540 --> 00:26:07,960
um , 64 jurisdictions Reminder 50 

610
00:26:07,960 --> 00:26:10,071
states , eight territories , five are 

611
00:26:10,071 --> 00:26:12,490
six metropolitan cities as well as five 

612
00:26:12,500 --> 00:26:15,320
federal agencies were down to our last 

613
00:26:15,320 --> 00:26:17,520
three . Uh , in fact , we're in 

614
00:26:17,520 --> 00:26:19,687
communications with three states right 

615
00:26:19,687 --> 00:26:21,631
now , and we think we'll have them 

616
00:26:21,640 --> 00:26:24,210
completed today . Or tomorrow is what I 

617
00:26:24,210 --> 00:26:26,266
was briefed this morning . Feel very 

618
00:26:26,266 --> 00:26:28,266
good about that . I have personally 

619
00:26:28,266 --> 00:26:31,100
talked to all three , uh , states about 

620
00:26:31,100 --> 00:26:34,660
this , and I feel good about it . Um , 

621
00:26:35,540 --> 00:26:38,350
thank you . Yeah . So it's a It's an 

622
00:26:38,350 --> 00:26:41,280
important question . The answer to 

623
00:26:41,290 --> 00:26:44,220
which can only be conceptual until we 

624
00:26:44,220 --> 00:26:46,331
actually know the performance off the 

625
00:26:46,331 --> 00:26:50,050
off the next vaccine . Now what the 

626
00:26:50,060 --> 00:26:52,760
criteria to be taken into account are 

627
00:26:53,140 --> 00:26:56,310
the actual efficacy level that the 

628
00:26:56,310 --> 00:26:59,880
vaccine has . I hope that most 

629
00:26:59,880 --> 00:27:02,080
vaccines that we will have will be in 

630
00:27:02,080 --> 00:27:04,840
the high eighties or 90% . There's a 

631
00:27:04,850 --> 00:27:08,060
there's a there's a a perception 

632
00:27:08,440 --> 00:27:11,560
associated with that that's important 

633
00:27:11,560 --> 00:27:13,727
and not to be neglected . But if there 

634
00:27:14,010 --> 00:27:16,232
if there was a gray agent on efficacy , 

635
00:27:16,440 --> 00:27:18,662
I think it would make sense to give the 

636
00:27:18,662 --> 00:27:20,773
highest FXC vaccine to those who have 

637
00:27:20,773 --> 00:27:22,960
the highest morbidity and mortality 

638
00:27:22,960 --> 00:27:25,890
from the disease and the slightly lower 

639
00:27:25,890 --> 00:27:28,170
efficacy . If that was to be the case , 

640
00:27:28,430 --> 00:27:31,880
toe more healthy , younger population , 

641
00:27:31,880 --> 00:27:34,170
I think the second point is the actual , 

642
00:27:34,180 --> 00:27:36,069
Asai said . The performance , the 

643
00:27:36,069 --> 00:27:38,630
performance of the vaccine in terms off 

644
00:27:38,640 --> 00:27:41,450
safety profile vaccine with MAWR 

645
00:27:41,840 --> 00:27:45,820
um acceptable react to Dennis ity 

646
00:27:45,820 --> 00:27:48,250
would need to go into populations that 

647
00:27:48,250 --> 00:27:51,030
have the higher benefit so again , 

648
00:27:51,040 --> 00:27:53,040
those that have more severe disease 

649
00:27:53,040 --> 00:27:55,207
consequences . And the vaccine that is 

650
00:27:55,207 --> 00:27:58,900
milder may need to go into ah , lower 

651
00:27:58,910 --> 00:28:01,860
risk population and then , frankly , 

652
00:28:01,860 --> 00:28:04,480
pragmatism , which is those 

653
00:28:04,480 --> 00:28:06,780
availability ? The way we designed our 

654
00:28:06,780 --> 00:28:09,380
strategy has been to give ourselves the 

655
00:28:09,380 --> 00:28:11,547
opportunity to have different vaccines 

656
00:28:11,660 --> 00:28:13,771
with different performance on the one 

657
00:28:13,771 --> 00:28:15,882
hand and spread our risk in case some 

658
00:28:15,882 --> 00:28:18,170
of them fail or are delayed . But 

659
00:28:18,170 --> 00:28:20,440
secondly , to accumulate vaccine , 

660
00:28:20,440 --> 00:28:22,880
Those is faster than with just one 

661
00:28:22,880 --> 00:28:25,180
supplier by having different vaccines , 

662
00:28:25,180 --> 00:28:27,291
a community , different doses through 

663
00:28:27,291 --> 00:28:29,890
different manufacturing sites . Thank 

664
00:28:29,890 --> 00:28:33,810
you . Next question . Our next question 

665
00:28:33,820 --> 00:28:36,480
comes from Graham . For Deano from 

666
00:28:36,480 --> 00:28:38,591
Buzzfeed Graham , your line is open . 

667
00:28:39,740 --> 00:28:41,851
Hi . Its dander Ghana with blood seed 

668
00:28:41,851 --> 00:28:44,170
news . Um , I have two questions , I 

669
00:28:44,170 --> 00:28:46,690
guess one for Dr Slowly . Which is how 

670
00:28:46,690 --> 00:28:48,579
would you compare the side effect 

671
00:28:48,579 --> 00:28:50,634
profiles you're seeing in the Pfizer 

672
00:28:50,634 --> 00:28:52,801
Moderna numbers to other vaccines that 

673
00:28:52,801 --> 00:28:54,746
people might take that you've seen 

674
00:28:54,746 --> 00:28:56,912
maybe the flu vaccine and others . The 

675
00:28:56,912 --> 00:28:58,912
second thing is , maybe for general 

676
00:28:58,912 --> 00:29:01,079
partner or secretary is our I'm really 

677
00:29:01,079 --> 00:29:03,190
just urging you to create a dashboard 

678
00:29:03,190 --> 00:29:05,190
with the distribution numbers , not 

679
00:29:05,190 --> 00:29:07,079
just keeping the state's reassure 

680
00:29:07,079 --> 00:29:07,070
people . That's been very helpful to 

681
00:29:07,070 --> 00:29:09,126
all of us in the news business . Not 

682
00:29:09,126 --> 00:29:11,459
really a question . Just an observation . 

683
00:29:11,459 --> 00:29:13,459
Thank you for that . And , uh , the 

684
00:29:13,459 --> 00:29:15,626
feedback on the dashboard question and 

685
00:29:15,626 --> 00:29:17,792
I'll work with General turn on looking 

686
00:29:17,792 --> 00:29:20,320
at that Dr . Slow . Right . So I would 

687
00:29:20,320 --> 00:29:23,400
say the vaccine that has the closer , 

688
00:29:23,410 --> 00:29:26,530
uh , local reactor , ethnicity and 

689
00:29:26,530 --> 00:29:28,641
systemic reactor Jenness ity . I used 

690
00:29:28,641 --> 00:29:30,920
the word reactor Jenness ity Not the 

691
00:29:30,920 --> 00:29:33,550
word safety because , frankly , safety , 

692
00:29:33,550 --> 00:29:36,360
it's all the same and they're all safe . 

693
00:29:37,140 --> 00:29:39,610
But the vaccines with similar local and 

694
00:29:39,610 --> 00:29:41,499
systemic reacted unity , which is 

695
00:29:41,499 --> 00:29:43,610
injection site tenderness , redness , 

696
00:29:43,610 --> 00:29:46,260
pain , headache , a little bit of fever , 

697
00:29:46,270 --> 00:29:49,590
all of the above , resolving within 24 

698
00:29:49,590 --> 00:29:53,330
to 36 hours for immunization , about 10 

699
00:29:53,330 --> 00:29:55,810
15% . Having what's called Great Tree , 

700
00:29:55,810 --> 00:29:57,866
which is not the maximum great great 

701
00:29:57,866 --> 00:30:00,910
for is the maximum . But greater is 

702
00:30:00,910 --> 00:30:04,800
significant , clearly noticeable 10 15% . 

703
00:30:04,800 --> 00:30:06,911
So the vaccine that's closest to that 

704
00:30:06,911 --> 00:30:09,022
is shin Greeks , another vaccine with 

705
00:30:09,022 --> 00:30:11,078
very , very high efficacy . Probably 

706
00:30:11,078 --> 00:30:13,189
there's no free lunch . If you have a 

707
00:30:13,189 --> 00:30:15,356
very good immune response , you notice 

708
00:30:15,356 --> 00:30:17,940
it . But it's not a safety issue . It 

709
00:30:17,940 --> 00:30:20,860
zits actually an immuno dynasty marker , 

710
00:30:21,240 --> 00:30:24,160
uh , and shingles . As I understand 

711
00:30:24,160 --> 00:30:27,270
Shing Greeks a zai understand is , uh 

712
00:30:27,640 --> 00:30:30,340
it's so effective and enormously used 

713
00:30:30,340 --> 00:30:32,284
to the extent that the competitors 

714
00:30:32,284 --> 00:30:34,284
vaccine has been withdrawn from the 

715
00:30:34,284 --> 00:30:36,229
market with no issues whatsoever . 

716
00:30:36,229 --> 00:30:38,284
Thank you . Next question , please . 

717
00:30:38,284 --> 00:30:40,229
Our next question comes from Carlo 

718
00:30:40,229 --> 00:30:42,396
Donald from Reuters News . Carl , your 

719
00:30:42,396 --> 00:30:43,396
line is open . 

720
00:30:46,140 --> 00:30:49,410
Uh , Carlo Donald from Reuters . Um , 

721
00:30:49,420 --> 00:30:52,930
just just curious . With vaccine doses 

722
00:30:52,940 --> 00:30:55,800
like begin being administered soon . Do 

723
00:30:55,800 --> 00:30:59,350
you guys have a plan for ? You know who 

724
00:30:59,350 --> 00:31:01,730
will receive that ? That first vaccine 

725
00:31:01,740 --> 00:31:04,090
that's gonna be done publicly if you 

726
00:31:04,100 --> 00:31:06,267
have any sense of where that does will 

727
00:31:06,267 --> 00:31:08,800
be administered or you know what ? What 

728
00:31:08,800 --> 00:31:11,022
type of personal will see that a health 

729
00:31:11,022 --> 00:31:13,244
care worker frontline work or something 

730
00:31:13,244 --> 00:31:13,060
like that ? Just curious if you have 

731
00:31:13,060 --> 00:31:16,260
any . Any planning on that ? Well , now 

732
00:31:16,260 --> 00:31:19,620
you make me feel as if we should . Uh , 

733
00:31:19,630 --> 00:31:22,340
General , we've been so focused on 

734
00:31:22,350 --> 00:31:24,461
speed , getting it out , deferring to 

735
00:31:24,461 --> 00:31:27,040
the governor's way have been deferring 

736
00:31:27,040 --> 00:31:28,929
to the governors , and we've been 

737
00:31:28,929 --> 00:31:31,110
deferring to the jurisdictions in the 

738
00:31:31,110 --> 00:31:34,450
cities . And so we probably do need to , 

739
00:31:34,460 --> 00:31:37,150
uh , make make a plan for you know 

740
00:31:37,150 --> 00:31:39,930
who's gonna get it first . Visibly , a 

741
00:31:39,930 --> 00:31:42,750
secretary a czar said Dr . Slowly said , 

742
00:31:42,750 --> 00:31:44,890
I apologize . I'm putting words on . 

743
00:31:44,890 --> 00:31:47,350
I've said we're all gonna be available 

744
00:31:47,870 --> 00:31:51,760
if it's appropriate . A time to be , uh , 

745
00:31:51,770 --> 00:31:53,881
receive the shot . And we're all more 

746
00:31:53,881 --> 00:31:55,992
than comfortable of getting it . Um , 

747
00:31:55,992 --> 00:31:58,770
you know , on TV , etcetera . But we 

748
00:31:58,770 --> 00:32:01,160
wanna work through , um , you know , 

749
00:32:01,170 --> 00:32:03,450
fair and equitable distribution and the 

750
00:32:03,450 --> 00:32:06,300
decisions by the governors , the 

751
00:32:06,310 --> 00:32:08,560
territories , and , you know the mayors 

752
00:32:08,560 --> 00:32:11,810
of cities accordingly on . And it's 

753
00:32:11,810 --> 00:32:14,510
just an important balance of not , uh , 

754
00:32:14,520 --> 00:32:18,120
showing favoritism , but making sure 

755
00:32:18,120 --> 00:32:22,080
that the people that you know a sip has 

756
00:32:22,080 --> 00:32:24,080
identified get the vaccine first in 

757
00:32:24,080 --> 00:32:27,350
their priorities . Six . A za general 

758
00:32:27,350 --> 00:32:29,461
mentioned I've I've made clear to the 

759
00:32:29,461 --> 00:32:31,683
team is I've made clear publicly to the 

760
00:32:31,683 --> 00:32:33,850
media and otherwise that I will gladly 

761
00:32:33,850 --> 00:32:35,683
get the 1st , 1st 1st shot first 

762
00:32:35,683 --> 00:32:37,628
vaccination . Just demonstrate the 

763
00:32:37,628 --> 00:32:39,294
American people might supreme 

764
00:32:39,294 --> 00:32:41,239
confidence in the integrity of the 

765
00:32:41,239 --> 00:32:43,350
process , the quality of the vaccines 

766
00:32:43,360 --> 00:32:45,416
and that I wouldn't ask the American 

767
00:32:45,416 --> 00:32:47,582
people to do something that I wouldn't 

768
00:32:47,582 --> 00:32:50,010
be willing to do myself right ? Next 

769
00:32:50,010 --> 00:32:52,660
question , please . Our next question 

770
00:32:52,660 --> 00:32:54,720
comes from John Collins from Science 

771
00:32:54,720 --> 00:32:56,831
magazine . John , your line is open . 

772
00:32:57,040 --> 00:32:58,984
Thanks for taking my call . I just 

773
00:32:58,984 --> 00:33:01,096
wanted to clarify something about the 

774
00:33:01,096 --> 00:33:03,318
fighter vaccine that Dr Slowey said . I 

775
00:33:03,318 --> 00:33:05,262
don't think you were implying that 

776
00:33:05,262 --> 00:33:07,429
people should just get one dose , so I 

777
00:33:07,429 --> 00:33:09,596
just wanted to clarify that point on . 

778
00:33:09,596 --> 00:33:11,818
The second question I have is about the 

779
00:33:11,818 --> 00:33:14,380
data coming from Russia on from China 

780
00:33:14,390 --> 00:33:17,280
of efficacy in press releases . But if 

781
00:33:17,280 --> 00:33:20,580
they were to apply for us from three 

782
00:33:20,580 --> 00:33:23,110
FDA and were to receive them with the U . 

783
00:33:23,110 --> 00:33:25,350
S . Government purchased those vaccine 

784
00:33:25,360 --> 00:33:27,416
and distribute them . When there's a 

785
00:33:27,416 --> 00:33:30,570
shortage of supply of other vaccine , I 

786
00:33:30,570 --> 00:33:32,737
will answer the second question , then 

787
00:33:32,737 --> 00:33:34,681
turned the doctor slowly about the 

788
00:33:34,681 --> 00:33:36,681
dosage . Uh , anybody is welcome if 

789
00:33:36,681 --> 00:33:38,903
they're subject to an i . N . D . Under 

790
00:33:38,903 --> 00:33:41,530
the FDA is clinical trial practices of 

791
00:33:41,540 --> 00:33:43,860
conducted their research consistent 

792
00:33:43,860 --> 00:33:46,250
with the human subject . Research 

793
00:33:46,250 --> 00:33:48,420
protection laws of the United States 

794
00:33:48,420 --> 00:33:50,730
and relevant treaties to submit their 

795
00:33:50,730 --> 00:33:53,290
data to apply for registration for 

796
00:33:53,290 --> 00:33:55,123
emergency use , authorization or 

797
00:33:55,123 --> 00:33:57,346
biologic license with the Food and Drug 

798
00:33:57,346 --> 00:33:59,568
Administration , where it would receive 

799
00:33:59,568 --> 00:34:01,568
full consideration . But that would 

800
00:34:01,568 --> 00:34:03,679
require , as the FDA is demonstrating 

801
00:34:03,679 --> 00:34:05,846
out by consideration of the Pfizer and 

802
00:34:05,846 --> 00:34:07,901
Madonna vaccine . Complete and utter 

803
00:34:07,901 --> 00:34:09,957
transparency and availability of all 

804
00:34:09,957 --> 00:34:12,179
data related to the clinical trials and 

805
00:34:12,179 --> 00:34:14,346
support to remember the FDA is looking 

806
00:34:14,346 --> 00:34:16,290
under the hood literally examining 

807
00:34:16,290 --> 00:34:18,234
every line of data every patient , 

808
00:34:18,234 --> 00:34:21,030
every patient identified in their , uh , 

809
00:34:21,040 --> 00:34:22,873
toe look through and confirm the 

810
00:34:22,873 --> 00:34:25,690
quality of the data . Eso they're open 

811
00:34:25,690 --> 00:34:27,801
for business , but you have to comply 

812
00:34:27,801 --> 00:34:29,690
with our rules to protect patient 

813
00:34:29,690 --> 00:34:31,857
safety . Start slowly . Yeah , I think 

814
00:34:31,857 --> 00:34:31,830
it's a really important point , they 

815
00:34:31,830 --> 00:34:34,180
said . secretary because that is one of 

816
00:34:34,180 --> 00:34:36,280
the comparing or most important 

817
00:34:36,280 --> 00:34:38,470
rationales off the time it's taking . 

818
00:34:38,470 --> 00:34:40,470
The FDA actually goes back into the 

819
00:34:40,470 --> 00:34:43,680
road data and re analyzes the data 

820
00:34:44,140 --> 00:34:46,250
rather than interpret 

821
00:34:48,040 --> 00:34:50,262
a table , for instance , it's out there 

822
00:34:50,262 --> 00:34:52,318
not suggesting anybody else has done 

823
00:34:52,318 --> 00:34:54,429
something wrong . I'm just describing 

824
00:34:54,429 --> 00:34:56,596
how the FDA does it . And John , thank 

825
00:34:56,596 --> 00:34:58,484
you very much for asking for that 

826
00:34:58,484 --> 00:35:00,429
clarification . I'm absolutely not 

827
00:35:00,429 --> 00:35:02,651
suggesting that the vaccine should be a 

828
00:35:02,651 --> 00:35:04,373
one does vaccine , because the 

829
00:35:04,373 --> 00:35:06,540
observation off that high efficacy was 

830
00:35:06,540 --> 00:35:09,920
only over a period off , uh , actually 

831
00:35:09,920 --> 00:35:13,110
10 , 8 days or nine days in the case of 

832
00:35:13,110 --> 00:35:15,277
fighter , and is only over a period of 

833
00:35:15,277 --> 00:35:17,332
three weeks . Maybe . In the case of 

834
00:35:17,332 --> 00:35:19,610
Moderna , it's very encouraging to say , 

835
00:35:19,610 --> 00:35:23,050
superfast onset of protection . The 

836
00:35:23,050 --> 00:35:25,650
second those is a full part of the 

837
00:35:25,650 --> 00:35:28,240
label . If the vaccines are approved , 

838
00:35:28,250 --> 00:35:30,970
it consolidates the immunity to to the 

839
00:35:31,440 --> 00:35:34,620
into the patient's against covered 19 . 

840
00:35:34,630 --> 00:35:37,570
And that's the data that shows long 

841
00:35:37,570 --> 00:35:40,020
lasting , at least over a few months , 

842
00:35:40,030 --> 00:35:42,620
immunity and unexpected to be very long 

843
00:35:42,620 --> 00:35:46,060
lasting . But so people should not take 

844
00:35:46,070 --> 00:35:48,237
the vaccine as a one does vaccine . We 

845
00:35:48,237 --> 00:35:50,970
do have the young sense vaccine that is 

846
00:35:50,970 --> 00:35:53,260
being tested as a one . Those vaccine 

847
00:35:53,840 --> 00:35:56,062
where the follow up will be long enough 

848
00:35:56,062 --> 00:35:58,300
to assess that we're not observing in a 

849
00:35:58,310 --> 00:36:02,130
micro event , but rather , uh , 

850
00:36:02,140 --> 00:36:04,910
long term . One could ask the question . 

851
00:36:04,910 --> 00:36:07,880
Why not run ? FXC tries with the one 

852
00:36:07,880 --> 00:36:10,102
Does vaccine of the Modern A vaccine or 

853
00:36:10,102 --> 00:36:12,213
the fighter vaccine ? That would be a 

854
00:36:12,213 --> 00:36:14,269
valid question . Off course . Timing 

855
00:36:14,269 --> 00:36:16,430
would be a big challenge . Dr . 

856
00:36:16,430 --> 00:36:18,486
Slaughter could actually interjected 

857
00:36:18,486 --> 00:36:20,319
and asked a follow up question . 

858
00:36:20,319 --> 00:36:22,541
Because I get this one from the media a 

859
00:36:22,541 --> 00:36:22,160
lot . I think it be helpful to have 

860
00:36:22,160 --> 00:36:24,360
your perspective there . The question 

861
00:36:24,360 --> 00:36:27,630
often comes up with the Pfizer 21 days 

862
00:36:27,690 --> 00:36:30,390
Madonna , 28 days to the second booster 

863
00:36:30,390 --> 00:36:33,110
shot that one would get . How precise 

864
00:36:33,120 --> 00:36:36,020
is that on the 21 or 28 days when a 

865
00:36:36,020 --> 00:36:38,076
patient comes back ? If they were to 

866
00:36:38,076 --> 00:36:39,890
come say the 22nd day , 23rd . 

867
00:36:39,890 --> 00:36:41,890
Obviously want everyone is close to 

868
00:36:41,890 --> 00:36:44,223
that is the prescribed days is possible . 

869
00:36:44,223 --> 00:36:46,279
But could you describe for the media 

870
00:36:46,279 --> 00:36:48,750
just interactions there ? So there are 

871
00:36:48,760 --> 00:36:51,440
there is the regulatory answer , and 

872
00:36:51,440 --> 00:36:53,580
there is a scientific , uh , 

873
00:36:53,590 --> 00:36:55,701
observations . I think the regulatory 

874
00:36:55,701 --> 00:36:58,100
answer is a vaccine is approved on a 0 

875
00:36:58,100 --> 00:37:00,790
21 days or 0 28 days . And that's what 

876
00:37:00,790 --> 00:37:03,020
should be done . Now , what does the 

877
00:37:03,020 --> 00:37:04,940
science say around that ? That 

878
00:37:04,940 --> 00:37:08,240
precision is not that important . What 

879
00:37:08,240 --> 00:37:10,240
we know with many other vaccines is 

880
00:37:10,240 --> 00:37:13,320
that the more you space , the two doses 

881
00:37:13,320 --> 00:37:15,542
of vaccine , the better immune response 

882
00:37:15,542 --> 00:37:17,709
to get after the second dose . But the 

883
00:37:17,709 --> 00:37:19,820
trade off is that you have a weaker , 

884
00:37:19,820 --> 00:37:22,270
potentially weaker protection between 

885
00:37:22,270 --> 00:37:24,590
the two doses . So when you're dealing 

886
00:37:24,590 --> 00:37:26,923
with the disease that has low incidence , 

887
00:37:27,010 --> 00:37:28,954
that's okay , because your risk of 

888
00:37:28,954 --> 00:37:31,010
contracting it is low in between the 

889
00:37:31,010 --> 00:37:33,380
doses . So , for instance , 06 months 

890
00:37:33,380 --> 00:37:35,850
is better than 02 months is better than 

891
00:37:35,850 --> 00:37:39,140
01 months is probably slightly better 

892
00:37:39,140 --> 00:37:42,950
than 0 21 days . But , uh , 

893
00:37:42,960 --> 00:37:45,340
if there is a significant transmission 

894
00:37:45,350 --> 00:37:47,461
of disease , as is the case here , we 

895
00:37:47,461 --> 00:37:49,572
should absolutely get the second does 

896
00:37:49,572 --> 00:37:51,683
exactly as has been studied . Great . 

897
00:37:51,683 --> 00:37:53,850
Thank you very much . Thank you . Next 

898
00:37:53,850 --> 00:37:57,530
question , please . Our next question 

899
00:37:57,530 --> 00:38:00,480
comes from Islam . Ahmed , from a sp , 

900
00:38:00,490 --> 00:38:03,680
Your line is open . Hi . Thank you so 

901
00:38:03,680 --> 00:38:06,030
much for doing that . Um , Dr Sorry . I 

902
00:38:06,030 --> 00:38:09,520
was wondering what you made off the in 

903
00:38:09,520 --> 00:38:12,720
the vaccine on the data that showed the 

904
00:38:12,730 --> 00:38:16,060
four cases off Bell's palsy . Is that 

905
00:38:16,070 --> 00:38:18,070
something Thio Watch out for Moving 

906
00:38:18,070 --> 00:38:20,237
forward is how concerned are you about 

907
00:38:20,237 --> 00:38:22,760
that ? Potentially or at all ? On the 

908
00:38:22,770 --> 00:38:26,100
second question , Waas Um , are we 

909
00:38:26,100 --> 00:38:29,320
fairly confident at this time that we 

910
00:38:29,320 --> 00:38:32,740
will see an immune , uh , memory B cell 

911
00:38:32,740 --> 00:38:35,340
response on so that the immune system 

912
00:38:35,340 --> 00:38:37,890
will mount antibodies further on down 

913
00:38:37,890 --> 00:38:39,890
the line ? Or do we just don't know 

914
00:38:39,890 --> 00:38:43,530
that yet ? Thank you . So I think the 

915
00:38:43,540 --> 00:38:45,550
first question on on safeties , 

916
00:38:45,900 --> 00:38:49,180
whichever are the serious adverse 

917
00:38:49,180 --> 00:38:52,380
events of interest of which policy 

918
00:38:52,380 --> 00:38:55,440
would be one . For instance , on the 

919
00:38:55,440 --> 00:38:58,700
Pfizer strategy as it's now public , 

920
00:38:58,700 --> 00:39:02,300
there are three active farmer 

921
00:39:02,300 --> 00:39:06,000
provisions observation studies , UH , 

922
00:39:06,010 --> 00:39:09,110
one the classic farmer conditions where 

923
00:39:09,120 --> 00:39:12,190
physicians or subjects patients called 

924
00:39:12,200 --> 00:39:15,460
back into the company one that uses the 

925
00:39:15,460 --> 00:39:19,090
V A and the Department of Defense data 

926
00:39:19,090 --> 00:39:22,780
sets on subjects immunized , and 

927
00:39:22,780 --> 00:39:24,724
one , an active health care worker 

928
00:39:24,724 --> 00:39:27,220
focused . 20,000 subjects follow up 

929
00:39:27,220 --> 00:39:30,420
city over three years that will detect , 

930
00:39:30,430 --> 00:39:33,300
uh , any significant adverse events . I 

931
00:39:33,300 --> 00:39:36,130
think here a large number and long term 

932
00:39:36,130 --> 00:39:39,140
follow up is the key and the capacity 

933
00:39:39,140 --> 00:39:41,980
to compare to an appropriate baseline 

934
00:39:42,340 --> 00:39:44,290
is the other key and frankly , the 

935
00:39:44,290 --> 00:39:46,690
appropriate baseline ISS , slightly 

936
00:39:46,690 --> 00:39:48,780
challenging in the sense that it's a 

937
00:39:48,780 --> 00:39:51,690
new baseline , because the pandemic 

938
00:39:51,700 --> 00:39:54,260
itself has changed the baseline 

939
00:39:54,260 --> 00:39:56,430
frequency of a number of events into 

940
00:39:56,430 --> 00:39:58,708
the population over the last 10 months . 

941
00:39:58,708 --> 00:40:01,041
So it's very important to take a recent , 

942
00:40:01,041 --> 00:40:04,470
almost concomitant baseline . As to the 

943
00:40:04,470 --> 00:40:06,210
memory question . All the data 

944
00:40:06,210 --> 00:40:08,321
generated with messenger on a vaccine 

945
00:40:08,321 --> 00:40:11,220
in small animals and large animal and 

946
00:40:11,220 --> 00:40:13,109
with other vaccines that I'm very 

947
00:40:13,109 --> 00:40:15,220
familiar with , as I was on the board 

948
00:40:15,220 --> 00:40:17,387
of Moderna before , is very clear that 

949
00:40:17,387 --> 00:40:19,790
you establish a very robust , long 

950
00:40:19,790 --> 00:40:22,510
lasting memory response also assessed 

951
00:40:22,510 --> 00:40:25,210
by detecting memory cells and , 

952
00:40:25,210 --> 00:40:27,154
importantly , looking at the Ricoh 

953
00:40:27,154 --> 00:40:30,310
response , the Global and ISA types all 

954
00:40:30,310 --> 00:40:32,450
the markers needed to tell you have a 

955
00:40:32,450 --> 00:40:34,506
robust ISA response , and you have a 

956
00:40:34,506 --> 00:40:37,850
robust memory response . And I think 

957
00:40:37,860 --> 00:40:40,760
this vaccines , therefore will have 

958
00:40:40,770 --> 00:40:44,070
long term memory and the protection 

959
00:40:44,210 --> 00:40:46,730
induced after one . Those in the 

960
00:40:46,730 --> 00:40:49,100
presence well , in the absence of 

961
00:40:49,100 --> 00:40:52,340
detective neutralizing antibodies , in 

962
00:40:52,340 --> 00:40:54,950
my view , is another demonstration that 

963
00:40:54,950 --> 00:40:58,940
this vaccine best way 

964
00:40:58,940 --> 00:41:01,162
to protect against this vaccine disease 

965
00:41:01,270 --> 00:41:03,720
is actually really a faster kinetic 

966
00:41:03,720 --> 00:41:06,380
immune response . It's a race between 

967
00:41:06,390 --> 00:41:08,770
speed of replication of the virus and 

968
00:41:08,770 --> 00:41:10,603
the speed of the immune response 

969
00:41:10,603 --> 00:41:13,080
mounting . If you are old , have a weak 

970
00:41:13,080 --> 00:41:15,247
immune system and your immune response 

971
00:41:15,247 --> 00:41:17,740
is slow . It will be very intense , but 

972
00:41:17,740 --> 00:41:20,620
it's slow by the time it intensifies . 

973
00:41:20,860 --> 00:41:22,860
You have a lot of our slowed . Have 

974
00:41:22,860 --> 00:41:24,749
lots offset infected . You are in 

975
00:41:24,749 --> 00:41:26,804
trouble . If you're immune responses 

976
00:41:26,804 --> 00:41:28,860
fast , you're asymptomatic or you're 

977
00:41:28,860 --> 00:41:30,804
just totally cleared . And I think 

978
00:41:30,804 --> 00:41:33,310
that's what we'll way would hypothesize 

979
00:41:33,310 --> 00:41:35,366
will be established in most people . 

980
00:41:35,366 --> 00:41:37,254
Immunized his memory That gives a 

981
00:41:37,254 --> 00:41:39,310
faster immune response and therefore 

982
00:41:39,310 --> 00:41:41,477
long lasting protection . Okay . Thank 

983
00:41:41,477 --> 00:41:43,199
you . Next question , please . 

984
00:41:49,910 --> 00:41:53,020
Do we have another question ? Yes . Um 

985
00:41:53,020 --> 00:41:55,187
my apologies . The next question comes 

986
00:41:55,187 --> 00:41:57,330
from John Hosie , Bloomberg News . 

987
00:42:00,100 --> 00:42:03,570
Hi . Thanks . Can you just clarify , um , 

988
00:42:03,580 --> 00:42:06,520
on the numbers and initial shipments 

989
00:42:06,530 --> 00:42:09,380
going out ? So we have it . Right ? Um , 

990
00:42:09,390 --> 00:42:11,168
it sounds like of the six point 

991
00:42:11,168 --> 00:42:14,520
4,000,005 , their doses 400,000 will be 

992
00:42:14,530 --> 00:42:17,060
held in reserve , and then half of the 

993
00:42:17,060 --> 00:42:19,520
remaining six will be held for a second 

994
00:42:19,520 --> 00:42:22,350
dose reserve . So three million initial 

995
00:42:22,350 --> 00:42:25,300
stop , uh , will go out in the first 

996
00:42:25,300 --> 00:42:27,860
round and then is the goal still have 

997
00:42:27,870 --> 00:42:29,648
20 million people vaccinated in 

998
00:42:29,648 --> 00:42:33,030
December . So the the answer to the 

999
00:42:33,100 --> 00:42:35,590
second question is we believe that 

1000
00:42:35,590 --> 00:42:37,730
there's there will be enough vaccine 

1001
00:42:37,730 --> 00:42:39,880
available for 20 million first 

1002
00:42:39,880 --> 00:42:42,102
vaccinations in the month of December . 

1003
00:42:42,200 --> 00:42:44,089
Let me ask General Tornado on the 

1004
00:42:44,089 --> 00:42:46,200
actual precise numbers from the first 

1005
00:42:46,200 --> 00:42:48,760
distribution Trump s . O . E rounded 

1006
00:42:48,760 --> 00:42:51,420
into the question . So I apologize . So 

1007
00:42:51,430 --> 00:42:55,240
a 6.4 , I pulled 500,000 for the 

1008
00:42:55,240 --> 00:42:58,010
reserve on . Then I divided the 

1009
00:42:58,010 --> 00:43:00,660
remaining , which meant 2.9 , uh , 

1010
00:43:00,670 --> 00:43:04,210
initial first dose and 2.9 2nd dose . 

1011
00:43:04,220 --> 00:43:06,430
Uh , I apologize . I did round for the 

1012
00:43:06,440 --> 00:43:08,607
for the response to the question three 

1013
00:43:08,607 --> 00:43:12,130
exact number is 6.4 pulled 500,000 . 

1014
00:43:12,500 --> 00:43:15,830
2.9 1st . Those 2.9 2nd does . 

1015
00:43:16,700 --> 00:43:18,811
Okay . Next question , please . Mhm . 

1016
00:43:19,800 --> 00:43:22,220
The next question is from Tom Powell , 

1017
00:43:22,220 --> 00:43:25,740
Washington Times Tom , go ahead . Hi , 

1018
00:43:25,750 --> 00:43:27,917
Tom Howell with The Washington Times . 

1019
00:43:27,917 --> 00:43:30,110
We talked about how the recent fighter 

1020
00:43:30,110 --> 00:43:32,166
data show there was protection after 

1021
00:43:32,166 --> 00:43:34,332
the first dose . It sounds like you're 

1022
00:43:34,332 --> 00:43:36,499
still planning the whole back Half the 

1023
00:43:36,499 --> 00:43:38,443
dose is to ensure supply . But has 

1024
00:43:38,443 --> 00:43:40,054
there been any late breaking 

1025
00:43:40,054 --> 00:43:42,110
consideration of just giving all the 

1026
00:43:42,110 --> 00:43:44,054
initial doses and then hoping that 

1027
00:43:44,054 --> 00:43:46,110
Pfizer ramps up its manufacturing in 

1028
00:43:46,110 --> 00:43:48,277
time , Uh , have it available within a 

1029
00:43:48,277 --> 00:43:50,443
reasonable amount of time , especially 

1030
00:43:50,443 --> 00:43:52,610
given what Dr Slowly said about how it 

1031
00:43:52,610 --> 00:43:54,832
doesn't have to be exactly 21 days or , 

1032
00:43:54,832 --> 00:43:56,721
you know , for that second dose . 

1033
00:43:56,721 --> 00:43:58,888
Thanks . Yes . So , Tom , thanks . And 

1034
00:43:58,888 --> 00:44:01,166
I'll ask the general of the doctor toe . 

1035
00:44:01,166 --> 00:44:03,499
Please add any color commentary on this . 

1036
00:44:03,499 --> 00:44:06,360
But , um , because the EU applications 

1037
00:44:06,360 --> 00:44:09,310
and hence the label from the FDA would 

1038
00:44:09,310 --> 00:44:12,060
likely , we assume , include both the 

1039
00:44:12,060 --> 00:44:14,060
first dose , followed by the second 

1040
00:44:14,060 --> 00:44:16,920
dose . Uh , we do believe whether from 

1041
00:44:16,920 --> 00:44:19,840
a held back reserve or from ongoing 

1042
00:44:19,850 --> 00:44:23,520
expected production of vaccine , we 

1043
00:44:23,520 --> 00:44:26,810
believe there needs to be , in our mind 

1044
00:44:27,090 --> 00:44:29,030
unavailable dose for that second 

1045
00:44:29,030 --> 00:44:32,250
administration of the vaccine . So we 

1046
00:44:32,250 --> 00:44:35,200
have done calculations of both what 

1047
00:44:35,200 --> 00:44:37,311
we're getting now , what we expect to 

1048
00:44:37,311 --> 00:44:39,790
get now and what the production lines 

1049
00:44:39,800 --> 00:44:42,330
show should be coming . And that's 

1050
00:44:42,330 --> 00:44:44,390
built into our forecast of what we 

1051
00:44:44,390 --> 00:44:46,501
believe we need to hold back . And as 

1052
00:44:46,501 --> 00:44:48,501
the general said , is , we get more 

1053
00:44:48,501 --> 00:44:50,557
experience on quality control on the 

1054
00:44:50,557 --> 00:44:52,279
production . We'll get greater 

1055
00:44:52,279 --> 00:44:54,460
confidence , of course , in the level 

1056
00:44:54,460 --> 00:44:56,890
of supply reserve we hold back for that 

1057
00:44:56,890 --> 00:44:59,420
second dose administration . But we 

1058
00:44:59,420 --> 00:45:02,750
will not distributed vaccine knowing 

1059
00:45:02,760 --> 00:45:05,530
that the booster will not be available 

1060
00:45:05,650 --> 00:45:08,550
either from reserve supply by us or 

1061
00:45:08,550 --> 00:45:10,860
from ongoing expected predicted 

1062
00:45:10,860 --> 00:45:13,230
production . And we're already working 

1063
00:45:13,230 --> 00:45:16,140
with manufacturers to maximize the full 

1064
00:45:16,140 --> 00:45:18,251
scale of their production . So that's 

1065
00:45:18,251 --> 00:45:21,800
built into our forecasts . I 

1066
00:45:21,810 --> 00:45:24,860
first I completely agree . I never 

1067
00:45:24,870 --> 00:45:27,120
suggested we should take a one . Those 

1068
00:45:27,120 --> 00:45:30,110
vaccine . I did specifically say the 

1069
00:45:30,110 --> 00:45:33,200
trade off when you space is you , may 

1070
00:45:33,200 --> 00:45:35,570
your protection may go down . It would 

1071
00:45:35,570 --> 00:45:38,770
be , I think , a mist ake unacceptable 

1072
00:45:38,770 --> 00:45:42,100
mistake to knowingly distribute the 

1073
00:45:42,100 --> 00:45:45,630
vaccine in non respect of the label . 

1074
00:45:45,860 --> 00:45:48,930
That would actually , I think , Dr 

1075
00:45:49,390 --> 00:45:52,360
the hesitation around the use of the 

1076
00:45:52,360 --> 00:45:54,780
vaccine high . So at least as an 

1077
00:45:54,780 --> 00:45:57,150
operation , there's never something we 

1078
00:45:57,150 --> 00:45:59,150
would recommend should be done . We 

1079
00:45:59,150 --> 00:46:01,206
need to comply with how the vaccines 

1080
00:46:01,206 --> 00:46:03,430
were tested and be optimally used . I 

1081
00:46:03,430 --> 00:46:05,152
think the second point is that 

1082
00:46:05,152 --> 00:46:07,152
unfortunately , the mathematics are 

1083
00:46:07,152 --> 00:46:09,319
misleading . The numbers we share with 

1084
00:46:09,319 --> 00:46:12,570
you our monthly numbers 40 million this 

1085
00:46:12,570 --> 00:46:14,570
month , 50 million next month . But 

1086
00:46:14,570 --> 00:46:16,514
that's not how life happens . Life 

1087
00:46:16,514 --> 00:46:18,900
happens is the 14 million this month is 

1088
00:46:18,900 --> 00:46:21,067
two million . This week , five million 

1089
00:46:21,067 --> 00:46:23,011
next week . Three million the week 

1090
00:46:23,011 --> 00:46:25,100
after seven million the week after . 

1091
00:46:25,430 --> 00:46:27,800
And therefore it's not Bullis . It's a 

1092
00:46:27,800 --> 00:46:31,180
rolling number . And therefore , if we 

1093
00:46:31,180 --> 00:46:33,291
were the only way I can tell you , we 

1094
00:46:33,291 --> 00:46:35,460
played the the mathematics and the 

1095
00:46:35,460 --> 00:46:38,040
modeling of that for a whole week 

1096
00:46:38,050 --> 00:46:40,161
because there is . There is almost an 

1097
00:46:40,161 --> 00:46:42,390
ethical question there that we wanted 

1098
00:46:42,390 --> 00:46:44,501
to make sure . What's the trade off ? 

1099
00:46:44,780 --> 00:46:47,360
And the trade off is about 1 to 1.5 

1100
00:46:47,370 --> 00:46:50,510
million people vaccinated with the risk 

1101
00:46:50,760 --> 00:46:53,000
off . Not giving the second does 

1102
00:46:53,000 --> 00:46:55,610
knowingly to people at the time they 

1103
00:46:55,610 --> 00:46:57,443
should have received it . And we 

1104
00:46:57,443 --> 00:46:59,443
decided that's not a risk we should 

1105
00:46:59,443 --> 00:47:01,554
take . Maybe , maybe by the middle of 

1106
00:47:01,554 --> 00:47:03,888
the amount of January or early February , 

1107
00:47:03,888 --> 00:47:07,230
when we have had 56 weeks of rolling hi 

1108
00:47:07,230 --> 00:47:10,090
cadence manufacturing and that we see 

1109
00:47:10,090 --> 00:47:12,460
that you know , things are rolling 

1110
00:47:12,460 --> 00:47:15,740
perfectly . We may and I did say it in 

1111
00:47:15,740 --> 00:47:18,870
other settings . I have never in 30 

1112
00:47:18,870 --> 00:47:22,640
years seen the launch of a new product 

1113
00:47:22,640 --> 00:47:24,920
without having built up a stock before 

1114
00:47:25,440 --> 00:47:27,810
in industry , and there's a reason why 

1115
00:47:27,810 --> 00:47:29,810
industry takes that financial hit . 

1116
00:47:30,080 --> 00:47:31,747
It's because we always know , 

1117
00:47:31,747 --> 00:47:34,110
particularly with biologicals , things 

1118
00:47:34,120 --> 00:47:36,120
could happen doesn't mean they will 

1119
00:47:36,120 --> 00:47:38,064
happen , but they could happen and 

1120
00:47:38,064 --> 00:47:40,176
therefore you build a stock . In this 

1121
00:47:40,176 --> 00:47:42,342
case , we have a pandemic . We need to 

1122
00:47:42,342 --> 00:47:44,564
people save people's life . We're gonna 

1123
00:47:44,564 --> 00:47:46,676
roll vaccine those as they come , but 

1124
00:47:46,676 --> 00:47:48,509
we're not certain they will come 

1125
00:47:48,509 --> 00:47:50,680
exactly as per plan . And as we said , 

1126
00:47:50,690 --> 00:47:52,246
you know , biologic protein 

1127
00:47:52,246 --> 00:47:56,160
manufacturing it it can be as much 

1128
00:47:56,170 --> 00:47:59,350
art form as it is science . And Dr 

1129
00:47:59,350 --> 00:48:01,572
Slowly , I think you've used the phrase 

1130
00:48:01,572 --> 00:48:03,572
before that , uh , that proteins or 

1131
00:48:03,572 --> 00:48:06,170
moody and we have to be very careful on 

1132
00:48:06,170 --> 00:48:08,337
production . That's really been one of 

1133
00:48:08,337 --> 00:48:10,337
the core elements of operation Warp 

1134
00:48:10,337 --> 00:48:12,226
speed . I think really one of the 

1135
00:48:12,226 --> 00:48:14,700
genius elements behind it was moving 

1136
00:48:14,700 --> 00:48:18,310
from clinical trial lot size production 

1137
00:48:18,620 --> 00:48:21,520
to commercial scale production early on 

1138
00:48:21,520 --> 00:48:23,990
in the development period , through the 

1139
00:48:24,270 --> 00:48:27,220
logistics , manufacturing and financial 

1140
00:48:27,220 --> 00:48:29,331
heft that we've been able to bring to 

1141
00:48:29,331 --> 00:48:31,670
the table to try to actually get there . 

1142
00:48:31,670 --> 00:48:33,540
Because there are often so many 

1143
00:48:33,540 --> 00:48:35,790
failures in the normal commercial bio 

1144
00:48:35,790 --> 00:48:38,430
pharma industry in that move , from 

1145
00:48:38,430 --> 00:48:40,374
clinical trial scale to commercial 

1146
00:48:40,374 --> 00:48:42,620
scale exercise , the system , get that 

1147
00:48:42,620 --> 00:48:45,820
done but still be cautious , especially 

1148
00:48:45,820 --> 00:48:47,810
in the early weeks and months of 

1149
00:48:47,810 --> 00:48:50,480
vaccine distribution because quality 

1150
00:48:50,480 --> 00:48:52,480
control issues , sterility issues . 

1151
00:48:52,480 --> 00:48:54,647
They happen in biologic manufacturer . 

1152
00:48:55,070 --> 00:48:57,292
If I if I couldn't secretary , just add 

1153
00:48:57,292 --> 00:48:59,126
two points to that . And I agree 

1154
00:48:59,126 --> 00:49:03,030
wholeheartedly with both comments . One , 

1155
00:49:03,040 --> 00:49:05,480
I use the term snap the chalk line . 

1156
00:49:05,490 --> 00:49:07,770
You know , it is about ensuring that 

1157
00:49:07,770 --> 00:49:10,830
the number that we allocate against 

1158
00:49:10,840 --> 00:49:13,750
allows the jurisdictions to do the 

1159
00:49:13,750 --> 00:49:17,090
detailed planning on the locations and 

1160
00:49:17,090 --> 00:49:19,146
the quantity they want sent to those 

1161
00:49:19,146 --> 00:49:21,730
locations , right ? So that we sure 

1162
00:49:21,740 --> 00:49:24,780
efficient and effective distribution 

1163
00:49:24,780 --> 00:49:27,290
and eventual use of the vaccine . The 

1164
00:49:27,290 --> 00:49:30,510
second point , I would tell everybody , 

1165
00:49:30,520 --> 00:49:34,000
is if your plan is based on perfection , 

1166
00:49:34,370 --> 00:49:37,900
I , Congar Inti , you execution will 

1167
00:49:37,900 --> 00:49:41,860
not equal perfection . So you have thio 

1168
00:49:41,870 --> 00:49:44,490
put things in place to mitigate , uh , 

1169
00:49:44,500 --> 00:49:47,550
where you're vulnerable and to allow us 

1170
00:49:47,550 --> 00:49:50,380
to , you know , adjust and make sure 

1171
00:49:50,390 --> 00:49:53,450
that everybody who gets there first 

1172
00:49:53,450 --> 00:49:55,860
those could get their second dose . We 

1173
00:49:55,860 --> 00:49:57,749
have time for one last question . 

1174
00:49:59,770 --> 00:50:03,330
Okay ? The last question comes from 

1175
00:50:03,330 --> 00:50:05,570
Rebecca Robins , New York Times . 

1176
00:50:05,580 --> 00:50:09,550
Rebecca , your line is open . Thank 

1177
00:50:09,550 --> 00:50:11,328
you for taking my question . My 

1178
00:50:11,328 --> 00:50:14,280
question pertains Thio the nursing home 

1179
00:50:14,290 --> 00:50:18,170
effort by CVS and Walgreen . Could you 

1180
00:50:18,170 --> 00:50:21,190
tell me when that will begin ? Or if 

1181
00:50:21,200 --> 00:50:24,000
the first shipment in the first 

1182
00:50:24,000 --> 00:50:26,278
allocations that states will be making . 

1183
00:50:26,278 --> 00:50:29,140
We'll be going exclusively to hospitals 

1184
00:50:29,140 --> 00:50:32,500
and health care centers and whether the 

1185
00:50:32,500 --> 00:50:34,500
nursing home effort what will start 

1186
00:50:34,500 --> 00:50:37,470
later ? Thank you , general . Sure s O . 

1187
00:50:37,480 --> 00:50:40,020
I just want Thio really applaud the 

1188
00:50:40,020 --> 00:50:43,120
great work by the C D . C uh , CVS , 

1189
00:50:43,120 --> 00:50:45,460
Walgreens and states in this effort . 

1190
00:50:45,460 --> 00:50:48,510
Right ? We , uh , roughly six weeks ago , 

1191
00:50:48,510 --> 00:50:50,677
maybe two months ago , I brought it as 

1192
00:50:50,677 --> 00:50:52,580
a course of action to them to 

1193
00:50:52,580 --> 00:50:56,040
prioritize , figure out a solution that 

1194
00:50:56,040 --> 00:50:58,820
could be implemented nationally . Um , 

1195
00:50:58,830 --> 00:51:01,680
that would best service , uh , provide 

1196
00:51:01,680 --> 00:51:04,500
support to these facilities on . I 

1197
00:51:04,500 --> 00:51:07,320
would tell you I received incredible 

1198
00:51:07,320 --> 00:51:10,390
updates on I'm excited about the plan . 

1199
00:51:10,760 --> 00:51:13,160
Number two , a zoo . We've talked about 

1200
00:51:13,170 --> 00:51:15,860
the plan we're implementing the states 

1201
00:51:15,860 --> 00:51:18,350
plans to their priorities . Uh , eso 

1202
00:51:18,350 --> 00:51:20,560
their determination of I would like it 

1203
00:51:20,560 --> 00:51:22,671
to go to the health care or long term 

1204
00:51:22,671 --> 00:51:24,504
health care facilities has to be 

1205
00:51:24,504 --> 00:51:27,990
identified first . As many as 36 states 

1206
00:51:27,990 --> 00:51:30,790
have already told the C D . C . A zm I 

1207
00:51:30,790 --> 00:51:32,734
update this morning that they want 

1208
00:51:32,734 --> 00:51:35,740
initial , uh , dosage to go to long 

1209
00:51:35,740 --> 00:51:37,990
term health care facilities . Uh , the 

1210
00:51:38,000 --> 00:51:41,470
CDC , Walgreens and CVS are working 

1211
00:51:41,470 --> 00:51:44,290
those plans . Uh , right now , the 

1212
00:51:44,290 --> 00:51:47,410
third thing is is that it is a not as 

1213
00:51:47,420 --> 00:51:51,310
easily , uh executed as easily said the 

1214
00:51:51,310 --> 00:51:53,470
amount of work that has to be done in 

1215
00:51:53,470 --> 00:51:55,692
collaboration and coordination with the 

1216
00:51:55,692 --> 00:51:58,390
actual sites , right , understanding 

1217
00:51:58,400 --> 00:52:00,710
the patients that air . They're making 

1218
00:52:00,710 --> 00:52:04,700
sure that all people are briefed 

1219
00:52:04,700 --> 00:52:07,420
and notified and people that care for 

1220
00:52:07,420 --> 00:52:09,950
those people are notified . All that 

1221
00:52:09,950 --> 00:52:12,150
collaboration has to occur , making 

1222
00:52:12,150 --> 00:52:13,960
sure the right sites , uh , to 

1223
00:52:13,960 --> 00:52:17,110
administer inside of the facilities 

1224
00:52:17,110 --> 00:52:20,550
already on that coordination . But that 

1225
00:52:20,550 --> 00:52:23,180
detail work has been done on . We're 

1226
00:52:23,180 --> 00:52:25,402
going to be ready to implement when the 

1227
00:52:25,402 --> 00:52:27,569
first wave goes out in accordance with 

1228
00:52:27,569 --> 00:52:31,220
state plans over great Well , um , to 

1229
00:52:31,220 --> 00:52:33,276
the member of the media . I hope you 

1230
00:52:33,276 --> 00:52:35,220
are finding these weekly briefings 

1231
00:52:35,220 --> 00:52:37,387
helpful . We intend to continue them . 

1232
00:52:37,387 --> 00:52:37,210
I also hope yesterday that you were 

1233
00:52:37,210 --> 00:52:40,030
able to watch the vaccine distribution 

1234
00:52:40,030 --> 00:52:42,086
summit meeting where you got to hear 

1235
00:52:42,086 --> 00:52:44,360
from leaders at CVS and Walgreens 

1236
00:52:44,360 --> 00:52:46,416
talking about their plans on nursing 

1237
00:52:46,416 --> 00:52:48,471
homes , but also more general retail 

1238
00:52:48,471 --> 00:52:50,582
distribution and how we're leveraging 

1239
00:52:50,582 --> 00:52:52,749
the normal vaccine and flu flu vaccine 

1240
00:52:52,749 --> 00:52:54,804
distribution systems that we have to 

1241
00:52:54,804 --> 00:52:57,350
get to hear from the's great logistics 

1242
00:52:57,350 --> 00:52:59,461
and distribution companies . McKesson 

1243
00:52:59,461 --> 00:53:02,360
FedEx ups who literally showed you the 

1244
00:53:02,360 --> 00:53:04,360
materials they're using to shipping 

1245
00:53:04,360 --> 00:53:06,582
McKesson , showing the actual kits that 

1246
00:53:06,582 --> 00:53:08,693
they put together in our direction of 

1247
00:53:08,693 --> 00:53:10,804
PP syringes , needles deal . You want 

1248
00:53:10,804 --> 00:53:13,010
to be able to administer vaccine and 

1249
00:53:13,010 --> 00:53:15,177
getting to hear from some of the great 

1250
00:53:15,177 --> 00:53:17,343
governors about how detailed the micro 

1251
00:53:17,343 --> 00:53:19,454
distribution planning has been at the 

1252
00:53:19,454 --> 00:53:21,399
state level . Working with General 

1253
00:53:21,399 --> 00:53:23,566
Pernis team in the C . D . C . To make 

1254
00:53:23,566 --> 00:53:23,360
that happen , I just hope you will 

1255
00:53:23,360 --> 00:53:25,416
assist us in getting word out to the 

1256
00:53:25,416 --> 00:53:27,638
American people so that they could have 

1257
00:53:27,638 --> 00:53:29,471
a high degree of confidence . As 

1258
00:53:29,471 --> 00:53:31,249
General Purna and each of those 

1259
00:53:31,249 --> 00:53:31,080
corporate leaders said , we're 

1260
00:53:31,080 --> 00:53:34,020
leveraging what already works every 

1261
00:53:34,020 --> 00:53:36,076
year in our system to distribute and 

1262
00:53:36,076 --> 00:53:37,964
vaccinate hundreds of millions of 

1263
00:53:37,964 --> 00:53:39,964
vaccinations every year , using the 

1264
00:53:39,964 --> 00:53:42,187
tried and true , using the systems that 

1265
00:53:42,187 --> 00:53:44,242
we know work . Or as they all said , 

1266
00:53:44,242 --> 00:53:47,670
this is what we do leverage that don't 

1267
00:53:47,670 --> 00:53:49,392
try to build something new and 

1268
00:53:49,392 --> 00:53:51,448
different . We have enough . We have 

1269
00:53:51,448 --> 00:53:53,392
enough variables on execution that 

1270
00:53:53,392 --> 00:53:55,392
we're managing through this cove it 

1271
00:53:55,392 --> 00:53:57,726
pandemic . Use the tried and true there , 

1272
00:53:57,726 --> 00:53:59,892
and I hope you'll help us with getting 

1273
00:53:59,892 --> 00:53:59,670
the word out to . People will have 

1274
00:53:59,670 --> 00:54:02,290
confidence that our military 100 are 

1275
00:54:02,290 --> 00:54:04,512
states or governors or private sector . 

1276
00:54:04,780 --> 00:54:06,947
They know how to do this . They'll get 

1277
00:54:06,947 --> 00:54:09,058
this job done , so thank you all very 

1278
00:54:09,058 --> 00:54:11,490
much and have a good rest of week that 

1279
00:54:11,490 --> 00:54:13,490
concludes today's briefing . Please 

1280
00:54:13,490 --> 00:54:15,490
send any follow up questions to our 

1281
00:54:15,490 --> 00:54:17,546
press office at media at HHS dot gov 

1282
00:54:17,546 --> 00:54:18,570
and have a good rest of the day .