1 00:00:00,240 --> 00:00:04,150 flower . Thank you , Michel . Good 2 00:00:04,150 --> 00:00:06,810 afternoon . Everybody on . Welcome to 3 00:00:06,810 --> 00:00:10,490 this final briefing for the year 2020 . 4 00:00:10,500 --> 00:00:13,170 Quite quite challenging and interesting . 5 00:00:13,540 --> 00:00:16,640 You're hopefully 2021 would be a 6 00:00:17,010 --> 00:00:19,020 better with better prospects going 7 00:00:19,030 --> 00:00:22,270 forward . ID like Thio brief . You 8 00:00:22,270 --> 00:00:25,190 really on a few topics . First on the 9 00:00:25,190 --> 00:00:28,290 science part of things . AstraZeneca Of 10 00:00:28,290 --> 00:00:30,401 course . The news of the day has bean 11 00:00:30,540 --> 00:00:33,640 news that the er , the UK regulatory 12 00:00:33,640 --> 00:00:35,640 agency has approved the AstraZeneca 13 00:00:35,640 --> 00:00:38,160 vaccine now and , uh , 14 00:00:42,140 --> 00:00:44,730 on the what we call the still does the 15 00:00:44,730 --> 00:00:46,900 same vaccine those as used in the face 16 00:00:46,900 --> 00:00:49,011 retrial conducted here in the U . S . 17 00:00:49,011 --> 00:00:50,956 With the AstraZeneca vaccine . But 18 00:00:50,956 --> 00:00:53,100 given three months apart , this is 19 00:00:53,110 --> 00:00:56,550 based on frankly more of a conceptual 20 00:00:56,560 --> 00:00:58,670 observation than 21 00:01:02,540 --> 00:01:04,960 face vaccine does is the better the 22 00:01:04,970 --> 00:01:07,137 response after the second does This is 23 00:01:07,137 --> 00:01:09,359 what known . But of course it's a trade 24 00:01:09,359 --> 00:01:11,303 off with the fact that people will 25 00:01:11,303 --> 00:01:13,510 spend as approved about three months 26 00:01:13,520 --> 00:01:17,150 after only one those has been given . 27 00:01:17,150 --> 00:01:19,070 And exactly the efficacy of the 28 00:01:22,640 --> 00:01:25,980 that is based on smaller number of 29 00:01:25,990 --> 00:01:28,690 cases and is about 50% The vaccine 30 00:01:28,690 --> 00:01:32,180 efficacy eyes very good against severe 31 00:01:32,180 --> 00:01:34,850 disease vaccine efficacy in the elderly , 32 00:01:34,850 --> 00:01:36,628 which as you know , is the most 33 00:01:36,660 --> 00:01:39,990 impacted population with this virus is 34 00:01:40,000 --> 00:01:43,120 actually effectively unknown . Because 35 00:01:43,120 --> 00:01:45,342 there were very few cases in the end of 36 00:01:45,342 --> 00:01:47,287 the population because of trials , 37 00:01:47,287 --> 00:01:50,520 adult time had not recruit too many 38 00:01:50,530 --> 00:01:53,050 elderly people . But that said , a very 39 00:01:53,050 --> 00:01:54,828 important step forward with the 40 00:01:54,828 --> 00:01:57,340 AstraZeneca Oxford vaccine . As you 41 00:01:57,340 --> 00:01:59,451 know , that vaccine is in phase three 42 00:01:59,451 --> 00:02:01,790 trial here in the US We have almost 43 00:02:01,790 --> 00:02:03,846 totally completed the recruitment of 44 00:02:03,846 --> 00:02:06,270 that tribe . We have 29,000 silent 700 45 00:02:06,270 --> 00:02:08,840 subjects in the study , out of about 46 00:02:08,850 --> 00:02:12,660 30,000 about planned on , uh , 47 00:02:13,340 --> 00:02:16,020 this is will start to accrue . We 48 00:02:16,020 --> 00:02:19,810 project if everything goes well , that , 49 00:02:19,990 --> 00:02:23,710 uh , read out on emergency use 50 00:02:23,710 --> 00:02:26,880 authorization may be granted somewhere , 51 00:02:26,890 --> 00:02:30,580 earning them April . And by that time , 52 00:02:30,740 --> 00:02:33,570 several tens of millions of those is 53 00:02:33,580 --> 00:02:35,358 off this vaccine . We have been 54 00:02:35,358 --> 00:02:38,370 manufactured at Emergent 55 00:02:38,740 --> 00:02:42,190 Onda . We have bean stockpiled and 56 00:02:42,190 --> 00:02:45,840 therefore will be available for use if 57 00:02:45,850 --> 00:02:48,680 data support its approval . As has just 58 00:02:48,680 --> 00:02:51,350 been the case with the immature is so 59 00:02:51,350 --> 00:02:54,410 important progress this week . In fact , 60 00:02:54,410 --> 00:02:56,960 this day second important point is the 61 00:02:56,960 --> 00:03:00,100 novel backs vaccine . The Novavax 62 00:03:00,110 --> 00:03:03,730 vaccine has started phase three trials 63 00:03:03,740 --> 00:03:07,000 on the 27th we already have 1000 64 00:03:07,000 --> 00:03:09,070 subjects recruited in the state . 65 00:03:12,740 --> 00:03:14,962 Any insights that will be participating 66 00:03:14,962 --> 00:03:17,350 participating in the trial had already 67 00:03:17,360 --> 00:03:19,580 been activated on our recruiting . The 68 00:03:19,590 --> 00:03:21,701 trial is being conducted currently in 69 00:03:21,701 --> 00:03:24,050 the U . S . And in Mexico , and may 70 00:03:25,040 --> 00:03:28,680 also includes on potentially Brazil . 71 00:03:28,850 --> 00:03:31,072 If we are able to bring these countries 72 00:03:31,100 --> 00:03:33,700 into the trial fast enough , it's very 73 00:03:33,700 --> 00:03:36,060 important that we recruit subjects here 74 00:03:36,060 --> 00:03:38,800 in the U . S . But also outside of the 75 00:03:38,800 --> 00:03:41,110 US because we project that there will 76 00:03:41,110 --> 00:03:44,740 be some challenges having subjects at 77 00:03:44,750 --> 00:03:46,694 TRIST , particularly the elderly , 78 00:03:46,740 --> 00:03:48,740 health care workers and people with 79 00:03:48,740 --> 00:03:50,851 calm abilities participating into the 80 00:03:50,851 --> 00:03:53,770 trial . When there is the moderna on 81 00:03:53,770 --> 00:03:56,140 the fighter and potentially over time , 82 00:03:56,150 --> 00:03:58,540 the young sons vaccines are available 83 00:03:58,540 --> 00:04:02,480 for use an immunization in Mass . The 84 00:04:02,490 --> 00:04:05,340 third point concerns of this great 85 00:04:05,340 --> 00:04:07,507 progress with the noble act . And , as 86 00:04:07,507 --> 00:04:09,729 you know , no relaxes the first protein 87 00:04:09,729 --> 00:04:11,784 vaccine to progress . It's in fact , 88 00:04:11,784 --> 00:04:13,840 the fifth out of six vaccines in our 89 00:04:13,840 --> 00:04:15,870 portfolio is progressing into phase 90 00:04:15,870 --> 00:04:18,900 three tribes about nine months after 91 00:04:18,900 --> 00:04:21,880 starting this endeavor eight months on 92 00:04:21,880 --> 00:04:25,540 a have . The next program is the J . 93 00:04:25,550 --> 00:04:28,430 J . Johnson's vaccine . You know , we 94 00:04:28,430 --> 00:04:30,319 announced last week that the face 95 00:04:30,319 --> 00:04:32,660 retrial recruitment has been completed 96 00:04:32,690 --> 00:04:35,850 on . We are very diligently working 97 00:04:35,860 --> 00:04:37,527 with the company and with the 98 00:04:37,527 --> 00:04:39,760 regulators . We feel more and more 99 00:04:39,760 --> 00:04:42,670 confident that readout of efficacy will 100 00:04:42,740 --> 00:04:45,260 take place during the month of January 101 00:04:45,340 --> 00:04:47,870 and very likely that an E way 102 00:04:47,870 --> 00:04:50,920 submission will take place during the 103 00:04:50,920 --> 00:04:53,790 month off January . So we didn't within 104 00:04:53,790 --> 00:04:56,650 the next four weeks and hopefully an 105 00:04:56,650 --> 00:04:59,450 approval may be reached in the first 106 00:04:59,450 --> 00:05:02,430 half of the month of February . And we 107 00:05:02,430 --> 00:05:05,220 are also working hard with the company 108 00:05:05,220 --> 00:05:07,590 and the FDA to further accelerate 109 00:05:07,590 --> 00:05:10,230 vaccine doses availability during the 110 00:05:10,230 --> 00:05:13,800 month off February . I think it can be 111 00:05:13,810 --> 00:05:16,430 quite a game changer . We're hopeful 112 00:05:16,430 --> 00:05:18,652 that this vaccine , which is a one shot 113 00:05:18,652 --> 00:05:20,986 vaccine , will have equivalent efficacy . 114 00:05:21,150 --> 00:05:24,300 Thio . Those of Modern and Pfizer 115 00:05:24,500 --> 00:05:27,490 will comment on that once we have the 116 00:05:27,500 --> 00:05:29,550 data that I'd like to attract your 117 00:05:29,550 --> 00:05:31,690 attention on on on the confidence 118 00:05:31,690 --> 00:05:35,130 intervals that are around H one of the 119 00:05:35,130 --> 00:05:37,530 numbers of horrific seed for fighter 120 00:05:37,530 --> 00:05:40,160 and Madonna 95% with the confidence 121 00:05:40,160 --> 00:05:43,730 interval between 89 100 meaning if they 122 00:05:43,730 --> 00:05:45,897 were to repeat these studies with same 123 00:05:45,897 --> 00:05:47,730 vaccine efficacy , we could come 124 00:05:47,730 --> 00:05:50,670 anywhere between 89% on 100% . 125 00:05:51,840 --> 00:05:55,280 The next point to raise your attention 126 00:05:55,280 --> 00:05:58,500 is on modern and fighter . We continue 127 00:05:58,500 --> 00:06:02,030 to have a good supply into the system 128 00:06:02,030 --> 00:06:04,960 and output of vaccine doses . General 129 00:06:04,960 --> 00:06:07,670 Prenup , Michael League and Partner 130 00:06:07,670 --> 00:06:09,503 will , of course , very few more 131 00:06:09,503 --> 00:06:11,670 authority on that . What I want to say 132 00:06:11,670 --> 00:06:13,670 is , with the modern a vaccine , we 133 00:06:13,670 --> 00:06:16,070 really would like to encourage Mawr 134 00:06:16,300 --> 00:06:18,189 adolescents to participate in the 135 00:06:18,189 --> 00:06:20,500 clinical trial . That's ongoing trial 136 00:06:20,510 --> 00:06:24,490 between the age of 12 and the age of 18 . 137 00:06:24,670 --> 00:06:27,010 We only have 22 subjects recruited in 138 00:06:27,010 --> 00:06:29,140 the study . We understand that it's a 139 00:06:29,140 --> 00:06:31,140 little bit of a challenge given the 140 00:06:31,140 --> 00:06:34,400 holiday season . But after the holidays , 141 00:06:34,620 --> 00:06:37,370 I think it's really important for Maura 142 00:06:37,370 --> 00:06:39,680 adolescents to participate in this 143 00:06:39,680 --> 00:06:41,569 clinical trial . This is a highly 144 00:06:41,569 --> 00:06:43,680 effective and very safe vaccine , and 145 00:06:43,680 --> 00:06:46,250 by participating in the trial , we will 146 00:06:46,640 --> 00:06:48,751 be able to accelerate the approval of 147 00:06:48,751 --> 00:06:51,220 this vaccine next to the Pfizer vaccine 148 00:06:51,230 --> 00:06:53,397 for use in this younger population . I 149 00:06:53,397 --> 00:06:55,640 think it's very important to do . We're 150 00:06:55,640 --> 00:06:57,640 also continuing to work with the 151 00:06:57,640 --> 00:07:00,150 company and with the FDA on potentially 152 00:07:00,150 --> 00:07:03,380 using a lower those into those 153 00:07:03,390 --> 00:07:06,490 immunization to increase the capacity 154 00:07:06,670 --> 00:07:09,150 faster . This is course only relevant 155 00:07:09,300 --> 00:07:11,780 if it can be done on a very short term 156 00:07:11,780 --> 00:07:15,360 basis . UH , continuing progress with 157 00:07:15,360 --> 00:07:17,304 Sanofi Vaccine , the other protein 158 00:07:17,304 --> 00:07:20,170 based vaccine . We are now looking at 159 00:07:20,170 --> 00:07:22,226 starting the face to be program . As 160 00:07:22,226 --> 00:07:25,060 for some of his press Ricky's hopefully 161 00:07:25,060 --> 00:07:27,550 by the middle of the month of February . 162 00:07:28,140 --> 00:07:31,070 On the therapeutic side of things , we 163 00:07:31,070 --> 00:07:34,340 have MAWR data on usage off the 164 00:07:34,340 --> 00:07:36,451 monoclonal antibodies . We raised the 165 00:07:36,451 --> 00:07:38,680 challenge that not enough off the mark 166 00:07:38,680 --> 00:07:40,402 antibody those is available in 167 00:07:40,402 --> 00:07:43,880 hospitals are actually being used . So 168 00:07:43,880 --> 00:07:45,936 there is good news , and that's good 169 00:07:45,936 --> 00:07:47,880 news . The good news is there is a 170 00:07:47,880 --> 00:07:50,047 progression weaken week on the usage , 171 00:07:50,047 --> 00:07:53,460 going from 10% last week to 20% . 172 00:07:53,840 --> 00:07:56,007 It's we the less good news . It's only 173 00:07:56,007 --> 00:07:58,173 20% and you really need to continue to 174 00:07:58,173 --> 00:08:00,680 work hard on the various reasons that 175 00:08:00,680 --> 00:08:03,830 are very , very pragmatic reasons why 176 00:08:03,840 --> 00:08:06,960 use is more limited . It's very 177 00:08:06,960 --> 00:08:09,680 important that way . Progress there . I 178 00:08:09,690 --> 00:08:12,010 will stop there and pass on Teoh . 179 00:08:12,020 --> 00:08:15,000 General partner will now review . Then 180 00:08:15,000 --> 00:08:17,222 we'll be happy to take your questions . 181 00:08:17,222 --> 00:08:19,500 Thank you . Great . Thanks , Dr Slowey , 182 00:08:19,500 --> 00:08:21,611 Uh , for everybody . Happy holidays . 183 00:08:21,611 --> 00:08:23,833 And thanks for being with us again this 184 00:08:23,833 --> 00:08:25,980 week . a sui tryto keep you updated 185 00:08:25,990 --> 00:08:27,990 with everything that we know that's 186 00:08:27,990 --> 00:08:30,110 going on . So this week , you know , 187 00:08:30,110 --> 00:08:32,221 we've provided jurisdictions with the 188 00:08:32,221 --> 00:08:35,280 final allocations of doses available . 189 00:08:35,280 --> 00:08:39,040 That means by tomorrow night , all the 190 00:08:39,050 --> 00:08:41,530 jurisdictions will be able to place 191 00:08:41,530 --> 00:08:44,630 orders for up to 20 million doses of 192 00:08:44,630 --> 00:08:46,990 vaccine , which has been collective 193 00:08:47,000 --> 00:08:50,020 over the last two weeks . Plus , since 194 00:08:50,030 --> 00:08:52,960 the first you A by Pfizer on then 195 00:08:52,960 --> 00:08:56,350 following you A by Madonna . We 196 00:08:56,360 --> 00:08:59,750 are really doing well , in my opinion , 197 00:08:59,750 --> 00:09:02,550 in the distribution , over 14 million 198 00:09:02,550 --> 00:09:04,717 doses of vaccine have been distributed 199 00:09:04,717 --> 00:09:07,140 to date . And every day we push mawr 200 00:09:07,140 --> 00:09:09,418 vaccine , I'll talk about that . A zoo . 201 00:09:09,418 --> 00:09:12,650 We go forward . In fact , this week we 202 00:09:12,650 --> 00:09:15,030 started not only pushing first those 203 00:09:15,030 --> 00:09:17,970 vaccine , but we started pushing second 204 00:09:17,970 --> 00:09:20,550 dose vaccine for the Pfizer vaccine 205 00:09:20,560 --> 00:09:23,270 Azaz . Uh , people who received the 206 00:09:23,280 --> 00:09:26,780 first dose around 4 January will start 207 00:09:26,780 --> 00:09:29,530 to be eligible for the second dose . We 208 00:09:29,530 --> 00:09:31,697 wanted to sure ensure that the vaccine 209 00:09:31,697 --> 00:09:33,863 was available . Toe all you know , the 210 00:09:33,863 --> 00:09:37,750 cadence for our execution is really 211 00:09:37,750 --> 00:09:40,830 coming into good posture . Uh , we're 212 00:09:40,830 --> 00:09:43,380 allocating to the States on Tuesday . 213 00:09:43,390 --> 00:09:45,590 States are available to order off the 214 00:09:45,590 --> 00:09:48,510 allocations on Thursday . We're picking 215 00:09:48,510 --> 00:09:52,380 and packing , uh , supplies , uh , 216 00:09:52,390 --> 00:09:54,680 to ensure it could be delivered by the 217 00:09:54,680 --> 00:09:57,450 following week . Really remarkable 218 00:09:57,450 --> 00:09:59,990 effort by the collective group of 219 00:10:00,140 --> 00:10:02,380 professionals , the men and women who 220 00:10:02,380 --> 00:10:04,520 have been working tirelessly from 221 00:10:04,520 --> 00:10:07,770 Pfizer , Moderna , McKesson , UPS and 222 00:10:07,770 --> 00:10:11,400 FedEx as they execute this every 223 00:10:11,400 --> 00:10:14,040 day on they are the ones that are 224 00:10:14,040 --> 00:10:16,370 executing the movement of the vaccine . 225 00:10:16,610 --> 00:10:19,570 I'd be remiss if I did not highlight 226 00:10:19,570 --> 00:10:22,970 the great work by the state and local 227 00:10:22,970 --> 00:10:26,750 governments . A zaid Do the planning on 228 00:10:26,750 --> 00:10:28,806 they determine the allocation at the 229 00:10:28,806 --> 00:10:30,690 state levels on the final 230 00:10:30,690 --> 00:10:32,850 administration , I think has been 231 00:10:32,850 --> 00:10:35,290 incredible task . So I just would like 232 00:10:35,290 --> 00:10:37,401 to take a minute as we close out this 233 00:10:37,401 --> 00:10:39,820 year to kind of think about where we've 234 00:10:39,820 --> 00:10:43,490 been over the last 7.5 plus months 235 00:10:43,500 --> 00:10:46,950 since Dr Slowly and I were notified 236 00:10:46,960 --> 00:10:49,930 on , you know , presented at the Rose 237 00:10:49,930 --> 00:10:52,940 Garden , uh , in May . So what we've 238 00:10:52,940 --> 00:10:55,730 done we've developed to safe and 239 00:10:55,730 --> 00:10:59,140 effective vaccines now for use 240 00:10:59,150 --> 00:11:01,094 authorized for use to the American 241 00:11:01,094 --> 00:11:03,261 people . We've scaled up manufacturing 242 00:11:03,261 --> 00:11:06,310 capacity in some cases building new 243 00:11:06,310 --> 00:11:08,421 brick and mortar from the ground up . 244 00:11:08,440 --> 00:11:11,480 We've issued 18 Defense Production Act 245 00:11:11,490 --> 00:11:14,340 ratings , which allows us to prioritize 246 00:11:14,340 --> 00:11:17,210 materials , supplies and equipment 247 00:11:17,220 --> 00:11:19,220 essential to the U . S . Government 248 00:11:19,220 --> 00:11:21,410 contracts . It puts them at the front 249 00:11:21,410 --> 00:11:23,880 of the line , hired and trained new 250 00:11:23,880 --> 00:11:25,940 staff and embedded logisticians and 251 00:11:25,940 --> 00:11:28,700 supply chain experts in all the 252 00:11:28,700 --> 00:11:31,150 manufacturing facilities . Aziz , we 253 00:11:31,150 --> 00:11:33,050 move forward . We developed and 254 00:11:33,050 --> 00:11:34,828 launched a new data system that 255 00:11:34,828 --> 00:11:38,330 connects hundreds of existing systems 256 00:11:38,330 --> 00:11:40,274 at the state and local level toe . 257 00:11:40,274 --> 00:11:42,910 Allow us to have visibility s so that 258 00:11:42,910 --> 00:11:45,230 we can see ourselves across the entire 259 00:11:45,230 --> 00:11:48,800 United States . We've executed 260 00:11:48,800 --> 00:11:51,870 extensive planning , uh , starting with 261 00:11:51,870 --> 00:11:53,759 the C . D . C . Putting out their 262 00:11:53,759 --> 00:11:55,620 playbook in September and then 263 00:11:55,620 --> 00:11:57,840 extensive coordinations with the state 264 00:11:57,840 --> 00:12:00,740 health officials every day , every week 265 00:12:00,740 --> 00:12:02,690 and every month since . And it 266 00:12:02,690 --> 00:12:05,620 continues As we go forward , we 267 00:12:05,620 --> 00:12:07,920 dedicated regional planning teams that 268 00:12:07,920 --> 00:12:11,020 are constantly available 24 hours a day , 269 00:12:11,020 --> 00:12:14,410 seven days a week at the CDC in support 270 00:12:14,420 --> 00:12:16,850 of the state and local governments . We 271 00:12:16,850 --> 00:12:20,090 provided I t specialist toe help all 272 00:12:20,090 --> 00:12:22,710 the jurisdictions to see themselves so 273 00:12:22,710 --> 00:12:24,980 that they understand exactly where 274 00:12:24,980 --> 00:12:27,750 everything is at a single point of time . 275 00:12:27,920 --> 00:12:30,550 They can plan and direct accordingly . 276 00:12:31,040 --> 00:12:34,400 We developed a program with C . D . C . 277 00:12:34,400 --> 00:12:37,170 Really developed a magnificent program , 278 00:12:37,180 --> 00:12:40,840 Thio , in collaboration with CVS and 279 00:12:40,840 --> 00:12:43,390 Walgreens to go toe all of our long 280 00:12:43,390 --> 00:12:45,690 term health care facilities on 281 00:12:45,690 --> 00:12:48,920 administer vaccine to really one of the 282 00:12:48,920 --> 00:12:51,560 two top priorities the elderly living 283 00:12:51,560 --> 00:12:55,350 in these homes . Over 906 clinics . Uh , 284 00:12:55,360 --> 00:12:58,270 conducted to date Aziz , we ramp up to 285 00:12:58,270 --> 00:13:01,830 4000 week . So really remarkable tasks . 286 00:13:01,840 --> 00:13:04,660 We've inked a partnership with 19 287 00:13:04,660 --> 00:13:07,880 pharmacy chains to ensure , as we go 288 00:13:07,880 --> 00:13:10,780 from stage one a toe , one B , that we 289 00:13:10,780 --> 00:13:14,410 can expand the capacity of distribution 290 00:13:14,640 --> 00:13:17,100 throughout the country , which gives 291 00:13:17,110 --> 00:13:19,780 everybody greater access to the vaccine . 292 00:13:19,790 --> 00:13:23,180 Uh , in each state assed directed by 293 00:13:23,180 --> 00:13:25,430 the governors on the state health 294 00:13:25,430 --> 00:13:28,200 officials , we funded distribution for 295 00:13:28,200 --> 00:13:31,980 vaccines alongside of ancillary kits to 296 00:13:31,980 --> 00:13:34,260 ensure that those things were there 297 00:13:34,340 --> 00:13:37,320 when they were needed on . We did this 298 00:13:37,330 --> 00:13:39,690 early on so that we had the right 299 00:13:39,700 --> 00:13:42,460 distribution mechanisms on the right 300 00:13:42,470 --> 00:13:44,760 ancillary kids to be distributed with 301 00:13:44,760 --> 00:13:48,230 the vaccine on . We provided dry ice , 302 00:13:48,240 --> 00:13:50,450 uh , to everybody that wants it . On 303 00:13:50,450 --> 00:13:53,100 the first replenishment for all Pfizer 304 00:13:53,100 --> 00:13:56,970 vaccines , we cut through the red tape 305 00:13:56,980 --> 00:13:59,880 right to ensure all the vaccines 306 00:13:59,890 --> 00:14:02,720 provided to Americans will be free of 307 00:14:02,720 --> 00:14:06,010 charge . And finally , as I started out 308 00:14:06,010 --> 00:14:08,760 with , we've allocated on will be 309 00:14:08,760 --> 00:14:11,010 available for final order in 20 million 310 00:14:11,010 --> 00:14:13,730 doses by this Thursday . Distributed 311 00:14:13,730 --> 00:14:16,970 more than 14 million doses of vaccine 312 00:14:16,970 --> 00:14:20,050 toe over 10,800 locations . 313 00:14:20,240 --> 00:14:23,210 Onda . We have administered over two 314 00:14:23,210 --> 00:14:25,940 million doses in the last two weeks . 315 00:14:25,950 --> 00:14:29,380 Really a remarkable feat on everybody 316 00:14:29,380 --> 00:14:31,420 Collectively should be very proud , 317 00:14:31,430 --> 00:14:33,390 right ? The federal government , 318 00:14:33,400 --> 00:14:37,090 industry , academia , uh , state and 319 00:14:37,090 --> 00:14:39,560 local governments . It has been a whole 320 00:14:39,570 --> 00:14:43,070 of America approach as we work 321 00:14:43,080 --> 00:14:46,110 every day to make sure that the vaccine 322 00:14:46,110 --> 00:14:49,530 gets to where it needs to be . We are 323 00:14:49,540 --> 00:14:52,060 out checking . Uh , yesterday I was 324 00:14:52,060 --> 00:14:55,240 able to go visit to hospitals , uh , in 325 00:14:55,240 --> 00:14:57,240 the local area , one in D . C . And 326 00:14:57,240 --> 00:14:59,960 went up in Maryland on I just saw 327 00:14:59,970 --> 00:15:03,360 remarkably dedicated staffs who are 328 00:15:03,360 --> 00:15:06,260 engaged , who understood the vaccines 329 00:15:06,270 --> 00:15:09,580 under their care who were involved in 330 00:15:09,580 --> 00:15:12,190 making sure that they were executing 331 00:15:12,340 --> 00:15:15,450 administration the right way to ensure 332 00:15:15,450 --> 00:15:17,339 that it's effectively used to the 333 00:15:17,339 --> 00:15:19,940 priorities of the governor's on 334 00:15:19,940 --> 00:15:22,273 implementation . I was highly impressed . 335 00:15:22,273 --> 00:15:25,390 Remarkably dedicated people working 336 00:15:25,400 --> 00:15:28,530 every day a Z go through this . They've 337 00:15:28,530 --> 00:15:31,360 done this over the last two weeks , um , 338 00:15:31,360 --> 00:15:34,230 through holidays , trying to give 339 00:15:34,240 --> 00:15:37,300 everybody some time off after a long 340 00:15:37,300 --> 00:15:40,260 year of fighting the virus . A zehr 341 00:15:40,260 --> 00:15:42,371 working through the administration of 342 00:15:42,371 --> 00:15:44,670 the vaccine , uh , to ensure that 343 00:15:44,670 --> 00:15:46,920 everybody gets it at a different time 344 00:15:46,920 --> 00:15:50,070 and not everybody at one time on then 345 00:15:50,070 --> 00:15:52,014 they've worked through three major 346 00:15:52,014 --> 00:15:54,710 snowstorms in the last two weeks and 347 00:15:54,710 --> 00:15:57,710 still really a remarkable job . So I 348 00:15:57,710 --> 00:15:59,580 just want to applaud everybody's 349 00:15:59,580 --> 00:16:02,830 efforts . Uh , collectively , over 350 00:16:02,840 --> 00:16:05,410 Aziz . We work through the vaccines , 351 00:16:05,420 --> 00:16:08,430 Uh , for the last 7.5 months , vaccines 352 00:16:08,430 --> 00:16:10,950 and therapeutics . Our responsibility 353 00:16:10,950 --> 00:16:13,850 is to ensure that we're delivering are 354 00:16:13,850 --> 00:16:15,870 developing , manufacturing , and 355 00:16:15,870 --> 00:16:19,150 delivering safe and effective vaccines 356 00:16:19,240 --> 00:16:21,670 and therapeutics to the American people . 357 00:16:22,040 --> 00:16:24,340 And so I just I'm just thrilled to be a 358 00:16:24,340 --> 00:16:26,840 part of this . And I'm excited about 359 00:16:26,850 --> 00:16:29,540 all the collaboration and great work 360 00:16:29,550 --> 00:16:32,450 that everybody has done to date . Thank 361 00:16:32,450 --> 00:16:36,060 you . Thank you to you both . 362 00:16:36,070 --> 00:16:38,310 Moderator will now open it up for 363 00:16:38,310 --> 00:16:40,477 questions as a reminder . Please state 364 00:16:40,477 --> 00:16:42,588 your name and outlets and please keep 365 00:16:42,588 --> 00:16:44,754 your questions as short as possible so 366 00:16:44,754 --> 00:16:46,977 we can get to as many as we can . Thank 367 00:16:46,977 --> 00:16:49,032 you as a reminder . If you'd like to 368 00:16:49,032 --> 00:16:51,460 ask a question , please Press star one 369 00:16:51,640 --> 00:16:53,807 a mute , your phone record , your name 370 00:16:53,807 --> 00:16:55,918 and your outlet clearly your name and 371 00:16:55,918 --> 00:16:57,973 outlet are required . Introduce your 372 00:16:57,973 --> 00:17:00,084 question . If you need to a draw your 373 00:17:00,084 --> 00:17:02,307 question . Press star to again to ask a 374 00:17:02,307 --> 00:17:04,362 question , please . Press star one . 375 00:17:04,362 --> 00:17:06,307 We'll go ahead and begin with Sara 376 00:17:06,307 --> 00:17:08,900 Gorman from Politico . Mr . Your line 377 00:17:08,900 --> 00:17:11,380 is now open . Hi . Thank you . This is 378 00:17:11,390 --> 00:17:13,950 Sarah over mall from Politico , Doctor . 379 00:17:13,950 --> 00:17:16,117 So I want to ask or you're breaking up 380 00:17:16,117 --> 00:17:18,061 a little bit in the beginning when 381 00:17:18,061 --> 00:17:20,117 you're talking about the AstraZeneca 382 00:17:20,117 --> 00:17:22,339 vaccine . Were you saying that you felt 383 00:17:22,339 --> 00:17:24,672 the British approval was premature ? Or ? 384 00:17:24,672 --> 00:17:26,839 I mean , since the U . S . People will 385 00:17:26,839 --> 00:17:29,061 be like you said months later . How are 386 00:17:29,061 --> 00:17:31,394 you scaring those two things ? And then , 387 00:17:31,394 --> 00:17:33,283 um , General e know that HHS said 388 00:17:33,283 --> 00:17:35,450 yesterday that there's some lag in the 389 00:17:35,450 --> 00:17:37,561 CDC numbers and vaccination . Right ? 390 00:17:37,561 --> 00:17:37,260 So what's the disparity there ? Like 391 00:17:37,260 --> 00:17:39,482 what ? How much of a lag is there ? And 392 00:17:39,482 --> 00:17:43,270 what are the real numbers ? Yeah , So I 393 00:17:43,280 --> 00:17:46,510 hope I hope you can hear me . Okay . Um , 394 00:17:46,510 --> 00:17:49,380 h R E is a science based , 395 00:17:49,530 --> 00:17:53,400 highly well skilled regulatory agency , 396 00:17:53,400 --> 00:17:56,540 and therefore , I am not raising any 397 00:17:56,540 --> 00:18:00,540 question as to the decision that 398 00:18:00,550 --> 00:18:04,090 they have made . Having said that , the 399 00:18:04,100 --> 00:18:06,590 requirements and the decision process 400 00:18:06,680 --> 00:18:09,230 as we have built it here in the U . S . 401 00:18:09,290 --> 00:18:11,320 Is what I can really comment on and 402 00:18:11,320 --> 00:18:15,270 what I know from within Onda That 403 00:18:15,270 --> 00:18:17,437 was the sense of my comments . Date of 404 00:18:17,437 --> 00:18:20,390 April E for emergency use authorization 405 00:18:20,400 --> 00:18:22,344 is based on completion of the face 406 00:18:22,344 --> 00:18:24,678 retrial that's being run here in the US , 407 00:18:24,678 --> 00:18:26,844 where we understand the clinical trial 408 00:18:26,844 --> 00:18:29,011 material that was used , how and where 409 00:18:29,011 --> 00:18:31,011 it was manufactured . We understand 410 00:18:31,011 --> 00:18:33,180 that immunization was has happened all 411 00:18:33,180 --> 00:18:36,280 the time , according to given those in 412 00:18:36,280 --> 00:18:38,530 the right schedule on the safety 413 00:18:38,530 --> 00:18:42,350 database is being agonal ized on 414 00:18:42,350 --> 00:18:44,580 degenerated exactly as has been the 415 00:18:44,590 --> 00:18:47,540 case for the other trials . I have no 416 00:18:47,540 --> 00:18:50,340 doubt that the vaccine is very 417 00:18:50,340 --> 00:18:53,010 effective against severe disease and is 418 00:18:53,010 --> 00:18:55,066 effective in the population where it 419 00:18:55,066 --> 00:18:57,100 was tested . For me , the biggest 420 00:18:57,100 --> 00:18:59,211 question mark , frankly , is efficacy 421 00:18:59,211 --> 00:19:01,433 in the elderly population that needs to 422 00:19:01,433 --> 00:19:03,378 be further documented just because 423 00:19:03,378 --> 00:19:05,322 there were not enough cases in the 424 00:19:05,322 --> 00:19:07,267 other because there was not enough 425 00:19:07,267 --> 00:19:09,322 elderly subjects included in the tri 426 00:19:09,322 --> 00:19:11,544 ALS . Early on , I know that there will 427 00:19:11,544 --> 00:19:13,489 be further analysis off the UK and 428 00:19:13,489 --> 00:19:17,450 Brazil trials that may actually give 429 00:19:17,460 --> 00:19:20,370 an information about that As far as the 430 00:19:20,370 --> 00:19:22,592 American people are concerned , I think 431 00:19:22,592 --> 00:19:24,759 it's important that we are able to say 432 00:19:24,759 --> 00:19:27,250 one vaccine has 95% epic . See , 433 00:19:27,370 --> 00:19:29,620 another vaccine has X percent . 434 00:19:29,620 --> 00:19:31,650 Whatever is that number , we need a 435 00:19:31,660 --> 00:19:35,210 clear and concrete number more than a 436 00:19:35,220 --> 00:19:38,260 number that is , you know , accumulated 437 00:19:38,260 --> 00:19:42,020 bye bye , adding together different 438 00:19:42,030 --> 00:19:45,230 trials with different schedules and 439 00:19:45,240 --> 00:19:48,590 different materials . So no criticism 440 00:19:48,600 --> 00:19:51,890 but more focused on how we are doing it . 441 00:19:51,890 --> 00:19:53,890 And it will be , of course , an FDA 442 00:19:53,890 --> 00:19:56,340 decision . Thio decide whether to 443 00:19:56,340 --> 00:19:59,000 consider also approval of the basis of 444 00:19:59,010 --> 00:20:02,290 the data that Macharia has 445 00:20:02,300 --> 00:20:05,700 used or not . I do want to add one 446 00:20:05,700 --> 00:20:07,700 thing as I have the microphone open 447 00:20:08,040 --> 00:20:11,460 just in to join general partner in 448 00:20:11,470 --> 00:20:13,637 banking and acknowledging the work off 449 00:20:13,637 --> 00:20:15,692 tens of thousands of people that are 450 00:20:15,692 --> 00:20:17,359 involved in the development , 451 00:20:17,359 --> 00:20:21,280 manufacture , supply , off the vaccine 452 00:20:21,280 --> 00:20:24,140 and administration of the vaccine and 453 00:20:24,150 --> 00:20:27,290 with the general we have towards So 454 00:20:27,290 --> 00:20:30,900 many agencies in the various states 455 00:20:30,910 --> 00:20:34,550 have agencies to discuss the 456 00:20:34,550 --> 00:20:36,272 rollout of the vaccine and the 457 00:20:36,272 --> 00:20:38,494 administration of the vaccine . We have 458 00:20:38,494 --> 00:20:40,590 engaged with all the players and all 459 00:20:40,590 --> 00:20:44,590 the parties involved in things process 460 00:20:44,630 --> 00:20:47,220 and heard their input on how we can 461 00:20:47,230 --> 00:20:50,320 optimize and maximize usage of the 462 00:20:50,320 --> 00:20:53,420 vaccine doses available we committed to 463 00:20:53,420 --> 00:20:56,240 have $20 million is distributed to the 464 00:20:56,240 --> 00:20:58,320 U . S population , and that's the 465 00:20:58,320 --> 00:21:00,850 number as an alterna , I said that 466 00:21:00,850 --> 00:21:02,970 would be actually available to take 467 00:21:02,970 --> 00:21:06,000 from a Zoff tomorrow , and 14 million 468 00:21:06,000 --> 00:21:08,640 doses are already where they should be 469 00:21:08,640 --> 00:21:11,710 administered . We have heard on agree 470 00:21:11,890 --> 00:21:14,230 that 2.1 million and frankly , I don't 471 00:21:14,240 --> 00:21:16,940 know the exact last number . 472 00:21:17,070 --> 00:21:20,720 It's in the system somewhere . There is 473 00:21:20,720 --> 00:21:22,950 a lag in how the numbers are computed , 474 00:21:23,050 --> 00:21:25,270 but surely it's a number that is 475 00:21:25,270 --> 00:21:28,110 smaller than the 14 million doses that 476 00:21:28,120 --> 00:21:31,280 are out there already available for use . 477 00:21:32,440 --> 00:21:34,890 We agree that that number is lower than 478 00:21:34,890 --> 00:21:38,570 what we hoped for . We philosophically , 479 00:21:38,570 --> 00:21:41,380 as we have always done , do not spend 480 00:21:41,380 --> 00:21:44,360 too much time describing a challenge . 481 00:21:44,470 --> 00:21:46,720 We then very quickly moved to 482 00:21:46,730 --> 00:21:49,320 addressing the challenge . And as we 483 00:21:49,320 --> 00:21:51,320 have always done , we would like to 484 00:21:51,320 --> 00:21:54,120 invite anybody that has energy to 485 00:21:54,120 --> 00:21:56,900 participate and help us further improve 486 00:21:56,900 --> 00:21:59,030 administration of the vaccine to come 487 00:21:59,030 --> 00:22:01,660 to the table , put your sleeves up and 488 00:22:01,660 --> 00:22:04,280 come help us with specific ideas . We 489 00:22:04,280 --> 00:22:06,280 know that it should be better , and 490 00:22:06,280 --> 00:22:08,447 we're working hard to make it better . 491 00:22:08,447 --> 00:22:10,391 So we welcome really very much any 492 00:22:10,391 --> 00:22:12,558 input , but it needs to be specific on 493 00:22:12,558 --> 00:22:15,750 action . Thank you . Yeah , but I don't 494 00:22:15,750 --> 00:22:18,083 know if you would like to add something . 495 00:22:18,083 --> 00:22:20,139 I'm in full support of what you just 496 00:22:20,139 --> 00:22:22,083 said , Dr . Slowey A T . End there 497 00:22:22,083 --> 00:22:24,610 accordingly . I would also say I'm 498 00:22:24,610 --> 00:22:28,190 working personally on a 72 to 499 00:22:28,190 --> 00:22:31,270 96 hour lag . Uh , that data will 500 00:22:31,270 --> 00:22:33,840 tighten up as we , uh you know , the 501 00:22:33,840 --> 00:22:36,830 systems and reporting becomes mawr 502 00:22:36,830 --> 00:22:40,510 regular and routine on . We'll adjust . 503 00:22:40,520 --> 00:22:43,340 You know that Lag , Aziz , we gain more 504 00:22:43,340 --> 00:22:47,060 data , but we absolutely are 505 00:22:47,070 --> 00:22:51,040 advocates of higher uptake . Andi , I 506 00:22:51,040 --> 00:22:53,700 have a lot of confidence personally 507 00:22:53,710 --> 00:22:57,160 that the state's attack , the state 508 00:22:57,160 --> 00:22:59,780 level and local levels are working this 509 00:22:59,790 --> 00:23:03,220 aggressively , especially as they 510 00:23:03,230 --> 00:23:05,710 execute . You know , one a priority 511 00:23:06,040 --> 00:23:09,090 with , uh , first line medical , 512 00:23:09,100 --> 00:23:12,190 uh , persons and then long term health 513 00:23:12,190 --> 00:23:14,570 care facilities to very difficult 514 00:23:14,570 --> 00:23:17,530 challenging groups . But the right 515 00:23:17,540 --> 00:23:20,440 groups . And so I am confident that 516 00:23:20,440 --> 00:23:23,050 everybody is working . It , um , the 517 00:23:23,060 --> 00:23:25,230 right way to make sure that the 518 00:23:25,230 --> 00:23:27,286 vaccines are most effective in those 519 00:23:27,286 --> 00:23:29,710 groups . Next question , please . 520 00:23:32,740 --> 00:23:34,851 Our next question comes from Angelica 521 00:23:34,851 --> 00:23:37,240 Libido from Bloomberg . Your line is 522 00:23:37,240 --> 00:23:40,430 now open . Hello . So during last 523 00:23:40,430 --> 00:23:42,486 week's briefing , you mentioned that 524 00:23:42,486 --> 00:23:44,597 the federal government has , um , the 525 00:23:44,597 --> 00:23:46,597 ability to help the state and local 526 00:23:46,597 --> 00:23:48,597 governments administrative vaccines 527 00:23:48,597 --> 00:23:50,890 faster . Um , so what exactly are you 528 00:23:50,890 --> 00:23:53,180 doing ? And will you need to readjust 529 00:23:53,190 --> 00:23:55,370 those plans , given that just a 530 00:23:55,370 --> 00:23:57,710 fraction of the doses distributed are 531 00:23:57,710 --> 00:24:00,910 actually being administered . So we 532 00:24:00,910 --> 00:24:02,799 always always have to continue to 533 00:24:02,799 --> 00:24:04,799 assess and adjust . I mean , that's 534 00:24:04,799 --> 00:24:07,360 what we do all the time in life , right ? 535 00:24:07,360 --> 00:24:09,480 We just don't keep walking straight 536 00:24:09,480 --> 00:24:11,591 ahead if things aren't going where we 537 00:24:11,591 --> 00:24:13,610 needed . So we assess , and we we 538 00:24:13,610 --> 00:24:15,850 continue to make adjustments . Aziz . 539 00:24:15,850 --> 00:24:18,530 Doctor , sla , we just said , and I'm 540 00:24:18,530 --> 00:24:21,470 going to add on on dso you know , what 541 00:24:21,470 --> 00:24:23,470 have we done ? We've worked hard to 542 00:24:23,470 --> 00:24:25,470 make sure the long term health care 543 00:24:25,470 --> 00:24:27,081 facilities we're ready to be 544 00:24:27,081 --> 00:24:29,192 implemented with great partnership of 545 00:24:29,192 --> 00:24:32,150 CVS and Walgreens , Uh , in the States 546 00:24:32,160 --> 00:24:34,930 on , I think you know that is gonna be 547 00:24:34,930 --> 00:24:38,230 a very , very sound program that in 548 00:24:38,230 --> 00:24:41,180 years to come will be used as a model . 549 00:24:41,540 --> 00:24:44,130 Second , a s'more vaccine becomes 550 00:24:44,130 --> 00:24:46,900 available , and we do see , you know , 551 00:24:46,900 --> 00:24:50,090 very good , steady drumbeat of our 552 00:24:50,090 --> 00:24:52,146 vaccine coming off the manufacturing 553 00:24:52,146 --> 00:24:54,312 and fill finish line . Uh , then we'll 554 00:24:54,312 --> 00:24:57,860 be able Thio expand distribution 555 00:24:58,040 --> 00:25:00,230 to through the local brick and mortar 556 00:25:00,230 --> 00:25:02,900 pharmacy . Change the 19 that I talked 557 00:25:02,900 --> 00:25:05,700 about . We want to enable the 558 00:25:05,700 --> 00:25:08,000 governor's plans , uh , to their 559 00:25:08,000 --> 00:25:11,390 priorities . And we think adding them 560 00:25:11,400 --> 00:25:15,020 right to the distribution matrix 561 00:25:15,030 --> 00:25:17,620 right through the provider agreements 562 00:25:17,620 --> 00:25:20,780 will expand capability and capacity of 563 00:25:20,780 --> 00:25:22,724 distribution throughout the entire 564 00:25:22,724 --> 00:25:24,850 country . There's over 70,000 565 00:25:25,040 --> 00:25:28,840 pharmacies , uh , already enrolled , uh , 566 00:25:28,850 --> 00:25:31,630 to do this on DSO As vaccine becomes 567 00:25:31,630 --> 00:25:33,680 available , states determined 568 00:25:33,690 --> 00:25:37,370 distribution priorities . I visualized 569 00:25:37,370 --> 00:25:41,030 as early as 8 January between eight and 570 00:25:41,030 --> 00:25:44,400 15 January , Theo expansion to their 571 00:25:44,400 --> 00:25:47,170 utilization will greatly increase 572 00:25:47,180 --> 00:25:49,360 access of vaccine to the American 573 00:25:49,360 --> 00:25:51,260 people on . Then we're just gonna 574 00:25:51,260 --> 00:25:54,180 continue on right Every every day . We 575 00:25:54,180 --> 00:25:56,820 have to assess every day . We have to 576 00:25:56,830 --> 00:26:00,040 keep pushing forward to ensure safe and 577 00:26:00,040 --> 00:26:03,340 effective vaccines are available to the 578 00:26:03,340 --> 00:26:06,460 American people . Thank you . Next 579 00:26:06,460 --> 00:26:10,400 question . The next couple 580 00:26:10,410 --> 00:26:12,466 couple . My next question comes from 581 00:26:12,466 --> 00:26:14,521 lower near guard from the Associated 582 00:26:14,521 --> 00:26:16,940 Press . Your line is now open . Hi . 583 00:26:16,950 --> 00:26:19,190 Thank you . Um , can you talk a little 584 00:26:19,190 --> 00:26:22,580 bit more about the decision by 585 00:26:22,590 --> 00:26:25,770 Britain today to actually allow longer 586 00:26:25,770 --> 00:26:28,050 lag between first dose and second dose 587 00:26:28,540 --> 00:26:31,450 is that something that scientifically 588 00:26:31,940 --> 00:26:34,340 makes sense And is that something that 589 00:26:34,350 --> 00:26:36,900 the U S might consider in trying to 590 00:26:36,900 --> 00:26:39,067 push out more first doses ? I know you 591 00:26:39,067 --> 00:26:40,956 all have been very careful to say 592 00:26:40,956 --> 00:26:43,067 You're gonna hold back in reserve the 593 00:26:43,067 --> 00:26:45,011 second dose for everyone who got a 594 00:26:45,011 --> 00:26:47,011 first dose so that there was no lag 595 00:26:47,011 --> 00:26:50,710 time . So , uh , yes , 596 00:26:50,720 --> 00:26:54,230 scientifically , uh , we and others 597 00:26:54,230 --> 00:26:56,890 have done experiment when I say we in 598 00:26:56,890 --> 00:27:00,450 my previous life , the other vaccines 599 00:27:01,040 --> 00:27:04,430 have shown that if you space the time 600 00:27:04,430 --> 00:27:07,330 between two vaccine doses zero on one 601 00:27:07,330 --> 00:27:10,380 month , 02 months , 06 months , you 602 00:27:10,380 --> 00:27:12,324 increasing your response after the 603 00:27:12,324 --> 00:27:15,650 second does . But I said each time when 604 00:27:15,650 --> 00:27:17,539 I spoke about that is to say , it 605 00:27:17,539 --> 00:27:21,260 really is important to have in mind the 606 00:27:21,470 --> 00:27:23,730 level of transmission off the Paterson 607 00:27:23,730 --> 00:27:25,860 that's happening in the population at 608 00:27:25,860 --> 00:27:28,150 that stage . Because efficacy after the 609 00:27:28,160 --> 00:27:31,790 first does maybe a challenge either the 610 00:27:31,790 --> 00:27:33,734 point efficacy . So in the case of 611 00:27:33,734 --> 00:27:36,970 Pfizer and Moderna , it's very high as 612 00:27:36,970 --> 00:27:39,910 of day 14 , but we don't know how long 613 00:27:39,920 --> 00:27:42,610 it stays , So it's very important to 614 00:27:42,610 --> 00:27:45,070 acknowledge that we are in the dark . 615 00:27:45,070 --> 00:27:48,680 There were toe space and in the case of 616 00:27:48,690 --> 00:27:51,200 the Z vaccine . The efficacy that's 617 00:27:51,200 --> 00:27:53,080 been described in a very small 618 00:27:53,090 --> 00:27:56,510 population in the tribe has received 619 00:27:56,510 --> 00:27:59,230 the space period of time with standard . 620 00:27:59,230 --> 00:28:03,000 Those is about 50% . 621 00:28:03,010 --> 00:28:05,130 So what ? You need to just be very 622 00:28:05,130 --> 00:28:07,130 clear in the communication , and it 623 00:28:07,130 --> 00:28:09,352 will depend on alternatives you have in 624 00:28:09,352 --> 00:28:11,574 your portfolio of vaccines , whether it 625 00:28:11,574 --> 00:28:15,210 is worth protecting at 95% those 626 00:28:15,210 --> 00:28:17,680 most impacted by the disease very 627 00:28:17,680 --> 00:28:20,010 quickly , or whether it's worth 628 00:28:20,270 --> 00:28:22,990 immunizing the broader population 629 00:28:23,160 --> 00:28:26,480 with the vaccine at 50% 630 00:28:26,490 --> 00:28:28,840 efficacy . And that is only relevant 631 00:28:28,840 --> 00:28:31,480 again if vaccine doses , as are 632 00:28:31,490 --> 00:28:34,500 available for very widespread using to 633 00:28:34,500 --> 00:28:37,620 the population . My understanding in 634 00:28:37,630 --> 00:28:40,350 the publications is that the UK has two 635 00:28:40,350 --> 00:28:43,870 million doses of vaccine available . Uh , 636 00:28:43,880 --> 00:28:46,870 for views a zoo now a number of those 637 00:28:46,870 --> 00:28:50,810 of vaccine become a larger as time goes 638 00:28:50,810 --> 00:28:54,030 by . So I think this address your 639 00:28:54,030 --> 00:28:56,252 question is it's an important one . But 640 00:28:56,252 --> 00:28:58,670 it's very important , I think , to use 641 00:28:58,670 --> 00:29:00,559 the vaccine based on how you have 642 00:29:00,559 --> 00:29:02,448 studied it . For me , the biggest 643 00:29:02,448 --> 00:29:05,060 concern if we were to extend the time 644 00:29:05,070 --> 00:29:07,237 period between the 1st and 2nd does is 645 00:29:07,237 --> 00:29:08,959 what happens to persistence of 646 00:29:08,959 --> 00:29:12,440 protection if we expand that period of 647 00:29:12,440 --> 00:29:14,830 time , It probably we could go down . 648 00:29:14,980 --> 00:29:17,170 And if it goes down , in what way does 649 00:29:17,170 --> 00:29:19,170 it go down ? Let's go down in a way 650 00:29:19,170 --> 00:29:21,580 that it's simply less efficacious or 651 00:29:21,590 --> 00:29:23,757 when we have some individuals that may 652 00:29:23,757 --> 00:29:25,979 have more severe disease or things like 653 00:29:25,979 --> 00:29:28,800 that . Uh , you know , I would really 654 00:29:28,800 --> 00:29:31,022 advise not to do something that we have 655 00:29:31,022 --> 00:29:33,130 no characterization off . And in the 656 00:29:33,130 --> 00:29:35,000 case of us is making a major . 657 00:29:36,940 --> 00:29:39,051 There is limited set of data . But at 658 00:29:39,051 --> 00:29:40,996 least there is some limited data . 659 00:29:40,996 --> 00:29:43,273 Their toe , nothing wrong is happening . 660 00:29:43,340 --> 00:29:46,950 The efficacy is moderate at 50% . Thank 661 00:29:46,950 --> 00:29:48,880 you . Thank you . Next question , 662 00:29:48,880 --> 00:29:51,770 please . The next question comes from 663 00:29:51,780 --> 00:29:54,113 Rebecca Robbins from The New York Times . 664 00:29:54,120 --> 00:29:57,050 Miss Robbins , your line is open . Well , 665 00:29:57,050 --> 00:29:59,110 thank you for taking my question . I 666 00:29:59,110 --> 00:30:01,370 was hoping you could speak Thio . The 667 00:30:01,380 --> 00:30:03,890 main factors that are driving the 668 00:30:03,900 --> 00:30:07,190 slower than expected uptake of vaccines , 669 00:30:07,200 --> 00:30:09,640 specifically the percentage administer 670 00:30:09,650 --> 00:30:11,928 compared to the percentage distributed . 671 00:30:11,928 --> 00:30:13,706 I know you mentioned the lag in 672 00:30:13,706 --> 00:30:15,817 reporting that I was hoping to hear , 673 00:30:15,840 --> 00:30:18,320 um , if you had a read on the other 674 00:30:18,320 --> 00:30:20,376 factors on the ground level that are 675 00:30:20,376 --> 00:30:22,040 influencing the flag . 676 00:30:24,740 --> 00:30:26,851 So you know , we're still we're still 677 00:30:26,851 --> 00:30:28,851 gathering data . The CDC is working 678 00:30:28,851 --> 00:30:31,610 diligently on that . Aziz , A work with 679 00:30:31,610 --> 00:30:34,740 the States . I do know that reporting 680 00:30:34,750 --> 00:30:37,460 has been really remarkable , uh , in 681 00:30:37,460 --> 00:30:40,270 its clarity , uh , to them and they're 682 00:30:40,270 --> 00:30:42,159 assessing and working through the 683 00:30:42,159 --> 00:30:44,790 details . I know there's an extensive 684 00:30:44,790 --> 00:30:46,910 amount of collaboration going on 685 00:30:46,910 --> 00:30:49,920 between the CDC , regional coordinators 686 00:30:49,920 --> 00:30:52,810 and each of the jurisdictions on states 687 00:30:52,810 --> 00:30:55,050 accordingly , Toe have greater 688 00:30:55,050 --> 00:30:57,430 specificity at this time . After two 689 00:30:57,430 --> 00:31:00,130 weeks , Uh , I don't think would be 690 00:31:00,130 --> 00:31:03,170 appropriate . I do believe has been 691 00:31:03,170 --> 00:31:06,780 reported to me is that vaccine 692 00:31:07,140 --> 00:31:10,430 allocations or uptake usually starts 693 00:31:10,430 --> 00:31:13,490 out a little slow on , then it then it 694 00:31:13,500 --> 00:31:16,770 increases exponentially . Uh , very 695 00:31:16,770 --> 00:31:19,510 rapidly , you know , Take take into 696 00:31:19,510 --> 00:31:22,060 effect . One that , you know . The 697 00:31:22,060 --> 00:31:24,370 Pfizer vaccine came out one week before 698 00:31:24,370 --> 00:31:26,590 the modern A vaccine . Essentially , 699 00:31:26,590 --> 00:31:29,050 it's been just 12 days . There's two 700 00:31:29,050 --> 00:31:31,240 holidays . There's been three major 701 00:31:31,240 --> 00:31:34,940 snowstorms . Uh , there is everybody 702 00:31:34,940 --> 00:31:37,310 working through . You know how to do 703 00:31:37,310 --> 00:31:39,310 the notification , how to make sure 704 00:31:39,310 --> 00:31:41,366 we're ministering it the right way , 705 00:31:41,366 --> 00:31:43,280 how to ensure that it stays in 706 00:31:43,280 --> 00:31:45,130 accordance with the cold chain . 707 00:31:45,140 --> 00:31:48,300 There's numerous factors on . Here's 708 00:31:48,300 --> 00:31:50,510 what I have confidence in . Every day 709 00:31:50,520 --> 00:31:53,570 everybody gets better on . I believe 710 00:31:53,570 --> 00:31:56,690 that uptake will increase , Uh , 711 00:31:56,700 --> 00:31:58,680 significantly as we go forward . 712 00:32:00,440 --> 00:32:02,662 Thank you . Thank you . Next question , 713 00:32:02,662 --> 00:32:04,960 please . Our next question comes from 714 00:32:04,970 --> 00:32:07,530 an 30 from ABC News . Your line is now 715 00:32:07,530 --> 00:32:10,200 open . Hi . Thank you for taking my 716 00:32:10,200 --> 00:32:12,660 question . Just , um , to build on that , 717 00:32:12,670 --> 00:32:14,781 based on what you've seen in the past 718 00:32:14,781 --> 00:32:16,948 15 days , does any of this adjust your 719 00:32:16,948 --> 00:32:19,114 timeline that the broader public would 720 00:32:19,114 --> 00:32:21,392 have access to these vaccines by April ? 721 00:32:25,540 --> 00:32:28,250 Well , in terms of vaccine doses 722 00:32:28,260 --> 00:32:32,130 available , manufactured , approved for 723 00:32:32,130 --> 00:32:35,080 use , uh , there is no reason to 724 00:32:35,080 --> 00:32:37,770 believe there will be any change way . 725 00:32:37,770 --> 00:32:40,230 Still believe , Of course , we know 726 00:32:40,230 --> 00:32:42,063 that the Moderna fighters in the 727 00:32:42,063 --> 00:32:44,810 vaccines are approved . A highly 728 00:32:44,810 --> 00:32:48,140 effective are being manufactured as per 729 00:32:48,140 --> 00:32:51,430 plan . We had planned 20 million doses 730 00:32:51,440 --> 00:32:54,350 again of the year . They are there 731 00:32:54,740 --> 00:32:56,907 there , you know our plans continue to 732 00:32:56,907 --> 00:32:59,570 be the same . I have each time 733 00:32:59,940 --> 00:33:02,610 cautioned that manufacturing the 734 00:33:02,610 --> 00:33:04,940 vaccine is very complex and therefore 735 00:33:04,950 --> 00:33:07,160 at some point there could be hiccups . 736 00:33:07,160 --> 00:33:09,980 But there's not at this stage , and 737 00:33:09,980 --> 00:33:11,924 therefore we will continue to have 738 00:33:11,924 --> 00:33:14,091 enough vaccine those to go through the 739 00:33:14,091 --> 00:33:15,869 adverse population and start to 740 00:33:15,869 --> 00:33:17,924 immunize , particularly as we signed 741 00:33:17,924 --> 00:33:19,869 the options with both Moderna Andi 742 00:33:19,869 --> 00:33:21,702 fighters to require another $100 743 00:33:21,702 --> 00:33:24,520 million from each , uh , to make 744 00:33:24,520 --> 00:33:26,520 vaccine available and immunized the 745 00:33:26,520 --> 00:33:28,798 general population in terms of vaccine , 746 00:33:28,798 --> 00:33:30,742 those availability and capacity to 747 00:33:30,742 --> 00:33:32,770 distribute it . And in addition , I 748 00:33:32,770 --> 00:33:34,826 remain very confident that the young 749 00:33:34,826 --> 00:33:37,180 sons vaccine will be available , 750 00:33:37,220 --> 00:33:40,290 probably in the month of February on . 751 00:33:40,290 --> 00:33:42,500 Remember that the vaccine based on on 752 00:33:42,500 --> 00:33:44,500 the tribesmen here yes , may become 753 00:33:44,500 --> 00:33:47,330 available in the month of April , and 754 00:33:47,330 --> 00:33:51,130 so could the The vaccine from Baba 755 00:33:51,140 --> 00:33:53,510 has just started . It's faced with 756 00:33:53,510 --> 00:33:57,020 trials , so from a from an availability 757 00:33:57,020 --> 00:34:00,140 standpoint , there is there is no 758 00:34:00,150 --> 00:34:03,120 knowledge from an administration 759 00:34:03,120 --> 00:34:05,453 standpoint . I concur , general partner , 760 00:34:05,453 --> 00:34:07,620 that you know there's a learning curve 761 00:34:07,620 --> 00:34:09,842 into the system and we're going through 762 00:34:09,842 --> 00:34:11,898 it , particularly a number of days . 763 00:34:11,898 --> 00:34:14,120 Have bean quote unquote lost because of 764 00:34:14,120 --> 00:34:16,740 the holidays or snowstorms or we're 765 00:34:16,740 --> 00:34:19,550 learning on will continue to learn and 766 00:34:19,550 --> 00:34:22,760 continue to listen and seek input 767 00:34:22,760 --> 00:34:25,260 specific input from others to help 768 00:34:25,270 --> 00:34:27,650 further accelerate the uptake . I think , 769 00:34:27,650 --> 00:34:30,250 as people see in the broad population , 770 00:34:30,640 --> 00:34:34,120 these vaccines are safe . People will 771 00:34:34,130 --> 00:34:37,740 again come forward mawr 772 00:34:37,740 --> 00:34:40,560 for vaccination As vaccines become 773 00:34:40,560 --> 00:34:42,727 available in pharmacies , I think it's 774 00:34:42,727 --> 00:34:44,950 gonna become more straightforward to go 775 00:34:44,950 --> 00:34:47,300 to a pharmacy and be immunized , so I 776 00:34:47,300 --> 00:34:51,070 expect that things will move back 777 00:34:51,160 --> 00:34:53,327 quickly . What we should be looking at 778 00:34:53,327 --> 00:34:56,320 is the rate of acceleration over the 779 00:34:56,320 --> 00:34:58,542 coming weeks . And I hope it will be in 780 00:34:58,542 --> 00:35:01,430 the right direction . Yeah . Thank you , 781 00:35:01,440 --> 00:35:03,551 Moderator . We have time for two more 782 00:35:03,551 --> 00:35:06,870 questions . Understood ? The first two 783 00:35:06,870 --> 00:35:08,870 is going to be Isaac Stanley Becker 784 00:35:08,870 --> 00:35:11,037 from Washington Post . Sir , your line 785 00:35:11,037 --> 00:35:13,090 is open . Hi . Thanks for doing the 786 00:35:13,090 --> 00:35:15,257 briefing and happy holidays . I wonder 787 00:35:15,257 --> 00:35:17,257 if I could ask just a couple really 788 00:35:17,257 --> 00:35:19,423 quick questions . One is that when you 789 00:35:19,423 --> 00:35:21,479 said that 14 million doses have been 790 00:35:21,479 --> 00:35:23,990 distributed , that's somewhat mawr than 791 00:35:23,990 --> 00:35:27,460 the CDC tracker is showing . Um , 792 00:35:27,470 --> 00:35:29,980 you have also an updated sense beyond 793 00:35:29,980 --> 00:35:33,090 the 2.1 dose is administered . Whether 794 00:35:33,090 --> 00:35:36,060 that already is somewhat greater over 795 00:35:36,060 --> 00:35:38,171 what the CDC tracker that hasn't been 796 00:35:38,171 --> 00:35:40,390 updated since Monday is showing . And 797 00:35:40,390 --> 00:35:42,501 then secondly , in terms of long term 798 00:35:42,501 --> 00:35:44,723 care facilities General , you mentioned 799 00:35:44,723 --> 00:35:46,890 last week that I believe 12 states had 800 00:35:46,890 --> 00:35:48,668 initiated that program in those 801 00:35:48,668 --> 00:35:50,557 facilities and that 13 additional 802 00:35:50,557 --> 00:35:52,890 states were expected to do so this week . 803 00:35:52,890 --> 00:35:55,001 Was that the case ? In terms of those 804 00:35:55,001 --> 00:35:57,001 13 And do you have a sense of , you 805 00:35:57,001 --> 00:35:59,057 know , next week or the week after ? 806 00:35:59,057 --> 00:36:02,050 How many more may initiate that ? So , 807 00:36:02,060 --> 00:36:04,790 to your first question , 14 million 808 00:36:04,790 --> 00:36:08,010 doses have been distributed . Uh , 809 00:36:08,020 --> 00:36:10,131 they're literally maybe some doses on 810 00:36:10,131 --> 00:36:13,060 the road right now as I speak . Um , 811 00:36:13,060 --> 00:36:16,260 but I feel very confident that 14 812 00:36:16,260 --> 00:36:17,950 million doses is what's being 813 00:36:17,950 --> 00:36:19,894 distributed , uh , to the American 814 00:36:19,894 --> 00:36:21,830 people . Uh , reference the 815 00:36:21,830 --> 00:36:25,290 jurisdictions . Um , we did last week . 816 00:36:25,300 --> 00:36:28,410 14 states did 906 817 00:36:28,420 --> 00:36:32,240 facilities . Uh , this week , 52 of 818 00:36:32,240 --> 00:36:35,930 55 jurisdictions have been enrolled in 819 00:36:35,930 --> 00:36:38,220 the process , and they're scheduled to 820 00:36:38,220 --> 00:36:41,860 do 4000 clinics this week alone . 821 00:36:42,130 --> 00:36:44,630 Which is why I believe the drum beat 822 00:36:44,630 --> 00:36:46,600 will occur the same way as we go 823 00:36:46,600 --> 00:36:49,840 forward . We are enacting , you know , 824 00:36:49,850 --> 00:36:53,180 we're enabling states plans . It's 825 00:36:53,180 --> 00:36:54,958 really important that the prior 826 00:36:54,958 --> 00:36:57,660 coordination with each facility is done 827 00:36:57,670 --> 00:36:59,114 so that we have the right 828 00:36:59,114 --> 00:37:01,114 administration done at at the right 829 00:37:01,114 --> 00:37:02,726 levels on . Then we have the 830 00:37:02,726 --> 00:37:05,059 appropriate amount of vaccine available . 831 00:37:05,059 --> 00:37:07,540 So depending on those two variables , I 832 00:37:07,540 --> 00:37:10,460 feel confident that we can keep a pace 833 00:37:10,460 --> 00:37:13,950 of 4000 , uh , clinics a 834 00:37:13,950 --> 00:37:17,290 week over . Thank you . Thank you . 835 00:37:17,290 --> 00:37:20,930 Moderator . One final question The last 836 00:37:20,930 --> 00:37:22,930 question comes from Elizabeth Weeks 837 00:37:22,930 --> 00:37:25,041 from U . S . A . Today , ma'am , your 838 00:37:25,041 --> 00:37:29,030 line is open . Hey , was 839 00:37:29,030 --> 00:37:32,350 I couldn't tell without my name . Yes , 840 00:37:32,350 --> 00:37:34,183 ma'am . Oh , good . Hi , this is 841 00:37:34,183 --> 00:37:36,183 Elizabeth . We thanks for taking my 842 00:37:36,183 --> 00:37:39,030 call . I wanted to ask how much of the 843 00:37:39,030 --> 00:37:42,760 disconnect is the hold back of vaccine 844 00:37:42,770 --> 00:37:44,770 for the long term care facilities ? 845 00:37:44,770 --> 00:37:46,881 Because , as I understand it , states 846 00:37:46,881 --> 00:37:48,937 that are part of that long term care 847 00:37:48,937 --> 00:37:51,214 facility program have toe hold back up . 848 00:37:51,214 --> 00:37:54,070 They have toe have at least half of the 849 00:37:54,070 --> 00:37:57,320 necessary vaccine already in house 850 00:37:57,320 --> 00:37:59,320 before they can launch . But it's a 851 00:37:59,320 --> 00:38:01,209 little murky to me . Can you give 852 00:38:01,209 --> 00:38:04,060 clarity on that ? So what we want to do 853 00:38:04,060 --> 00:38:05,949 is make sure that the appropriate 854 00:38:05,949 --> 00:38:08,004 amount of vaccines available so that 855 00:38:08,004 --> 00:38:10,000 when , um , CVS and Walgreens 856 00:38:10,010 --> 00:38:12,940 coordinate times for the clinics that 857 00:38:12,940 --> 00:38:16,740 we are able to do everybody inside of 858 00:38:16,750 --> 00:38:19,170 the facility . Both , um , both the 859 00:38:19,170 --> 00:38:22,240 elderly Aziz , Well as those caring for 860 00:38:22,240 --> 00:38:25,540 him and so really important . Aziz , we 861 00:38:25,540 --> 00:38:29,120 ramp up the total execution that the 862 00:38:29,120 --> 00:38:32,070 vaccines available , so yes , that does 863 00:38:32,070 --> 00:38:35,070 contribute to part of the lag . Andi , 864 00:38:35,070 --> 00:38:37,980 it could be a good significant number . 865 00:38:37,990 --> 00:38:40,750 A couple 100 million uh , for sure . 866 00:38:40,760 --> 00:38:43,440 Aziz , we go forward because we're 867 00:38:43,440 --> 00:38:46,040 working these every day , as I said , 868 00:38:46,050 --> 00:38:48,780 And every day they don't get registered 869 00:38:48,780 --> 00:38:51,510 until the vaccine gets administered on . 870 00:38:51,510 --> 00:38:53,399 So it's a great point that you're 871 00:38:53,399 --> 00:38:55,580 bringing up and clearly could be part 872 00:38:55,590 --> 00:38:58,190 of , you know , the lag in the numbers 873 00:38:58,200 --> 00:39:01,070 soem or to follow on that if I could 874 00:39:01,070 --> 00:39:03,350 Well , I have the mic open . I made a 875 00:39:03,350 --> 00:39:06,900 misquote earlier questioning . I 876 00:39:06,910 --> 00:39:09,160 said that there would be 70,000 877 00:39:09,160 --> 00:39:12,350 pharmacies available . Aziz , we expand 878 00:39:12,360 --> 00:39:14,940 availability and distribution for 879 00:39:14,940 --> 00:39:17,162 greater availability . Really ? We have 880 00:39:17,162 --> 00:39:20,950 70,000 providers enrolled , uh , you 881 00:39:20,950 --> 00:39:22,839 know , which includes hospitals , 882 00:39:22,839 --> 00:39:24,950 doctors , offices and pharmacies . We 883 00:39:24,950 --> 00:39:28,790 have 40,000 pharmacies enrolled on . I 884 00:39:28,790 --> 00:39:30,790 just wanted to clarify that for the 885 00:39:30,790 --> 00:39:33,270 record , Thank you . Thank you , 886 00:39:33,270 --> 00:39:35,603 General Partner . Thank you , Dr Slowey . 887 00:39:35,603 --> 00:39:37,659 Again , follow up . Questions can be 888 00:39:37,659 --> 00:39:39,714 sent to media at HHS dot gov On with 889 00:39:39,714 --> 00:39:41,492 that , I'll hand it over to the 890 00:39:41,492 --> 00:39:43,714 operator to finish out the call . Thank 891 00:39:43,714 --> 00:39:43,250 you all . Happy New Year .